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Clinics and Practice
Volume 2
Issue 4
10.4081/cp.2012.e83
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Clinics and Practice is published by MDPI from Volume 11 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Autoimmune Hepatitis Induced by Nitrofurantoin. The Importance of the Autoantibodies for an Early Diagnosis of Immune Disease

by
Jagannath M. Sherigar
1,*,
Richard Fazio
2,
Minsheng Zuang
3 and
Edward Arsura
4
1
Department of Internal Medicine, Northwest Mississippi Regional Medical Center, Clarksdale, MS, USA
2
Department of Gastroenterology, Richmond University Medical Center, Staten island, NY, USA
3
Department of Pathology, Richmond University Medical Center, Staten island, NY, USA
4
Department of Internal Medicine, Richmond University Medical Center, Staten island, NY, USA
*
Author to whom correspondence should be addressed.
Clin. Pract. 2012, 2(4), e83; https://doi.org/10.4081/cp.2012.e83
Submission received: 11 March 2012 / Revised: 21 August 2012 / Accepted: 30 August 2012 / Published: 17 October 2012

Abstract

Nitrofurantoin has been in use since 1953 as an effective agent for the prevention of recurrent urinary tract infection. It is associated with a wide range of adverse drug reactions. Chronic active hepatitis has increasingly been observed and many cases have been reported with case fatalities. We present a case of nitrofurantoin induced chronic active hepatitis and briefly review the serology and clinico pathological features of 57 similar cases reported in English literature. The consistent presence of antinuclear antibody, anti smooth muscle antibody, elevated immunoglobulin and pathological feature suggests an immunologic mechanism. Complete recovery is possible in most cases if medication is discontinued in time. Steroids may play a role in management if no improvement occurs despite discontinuation of medication. We suggest all patients who are on prolonged nitrofurantoin therapy be followed up with anti nuclear antibody, anti smooth muscle antibody, serum immunoglobulin and hepatic panel every three months.
Keywords: chronic active hepatitis; anti nuclear antibody; anti smooth muscle antibody; nitrofurantoin; hepatotoxicity chronic active hepatitis; anti nuclear antibody; anti smooth muscle antibody; nitrofurantoin; hepatotoxicity

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MDPI and ACS Style

Sherigar, J.M.; Fazio, R.; Zuang, M.; Arsura, E. Autoimmune Hepatitis Induced by Nitrofurantoin. The Importance of the Autoantibodies for an Early Diagnosis of Immune Disease. Clin. Pract. 2012, 2, e83. https://doi.org/10.4081/cp.2012.e83

AMA Style

Sherigar JM, Fazio R, Zuang M, Arsura E. Autoimmune Hepatitis Induced by Nitrofurantoin. The Importance of the Autoantibodies for an Early Diagnosis of Immune Disease. Clinics and Practice. 2012; 2(4):e83. https://doi.org/10.4081/cp.2012.e83

Chicago/Turabian Style

Sherigar, Jagannath M., Richard Fazio, Minsheng Zuang, and Edward Arsura. 2012. "Autoimmune Hepatitis Induced by Nitrofurantoin. The Importance of the Autoantibodies for an Early Diagnosis of Immune Disease" Clinics and Practice 2, no. 4: e83. https://doi.org/10.4081/cp.2012.e83

APA Style

Sherigar, J. M., Fazio, R., Zuang, M., & Arsura, E. (2012). Autoimmune Hepatitis Induced by Nitrofurantoin. The Importance of the Autoantibodies for an Early Diagnosis of Immune Disease. Clinics and Practice, 2(4), e83. https://doi.org/10.4081/cp.2012.e83

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