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Clinics and Practice, Volume 15, Issue 10

2025 October - 19 articles

Cover Story: Serum sickness-like reaction (SSLR) is an uncommon immune system disorder characterized by the classic triad of fever, rash, and articular involvement following recent exposure to various triggers, including infectious diseases (predominantly viral), drugs (mostly antibiotics and monoclonal antibodies), and, less frequently, vaccines. Although the clinical presentation and management of SSLR resemble those of serum sickness, the two conditions differ in etiology, mechanisms, and pathology. The lack of high-quality evidence and formal guidelines limits current understanding of the immunopathology and management of SSLR. This narrative review summarizes available data on the epidemiology, pathophysiology, clinical features, diagnosis, and treatment of SSLR, and highlights the need for further research to clarify unresolved issues. View this paper
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Articles (19)

  • Article
  • Open Access
787 Views
18 Pages

Trends and Hot Spots in Research Related to Rivaroxaban: Bibliometric Analysis

  • Kornel Pawlak,
  • Łukasz Kruszyna,
  • Anna Wesołowska and
  • Marta Karaźniewicz-Łada

21 October 2025

Background: The number of publications related to rivaroxaban is growing, making it difficult for scientists to review relevant materials. Objectives: This bibliometric analysis is focused on highlighting hot spots and new trends associated with riva...

  • Review
  • Open Access
3,810 Views
14 Pages

Kidney and Pregnancy: A Comprehensive Review

  • Luca Piscitani,
  • Paolo Sipari,
  • Lorenzo Ottavio Di Pietro,
  • Sofia Bussolaro,
  • Maurizio Guido and
  • Ilaria Fantasia

20 October 2025

During pregnancy, a series of physiological changes occur in women, particularly affecting the cardiovascular system with significant hemodynamic alterations. Subsequently, this leads to renal adaptations manifesting through variations in glomerular...

  • Article
  • Open Access
3,132 Views
14 Pages

18 October 2025

Background/Objectives: Coagulopathy is a common complication of liver cirrhosis, partly due to impaired synthesis of vitamin K-dependent coagulation factors. Despite its frequent use, the efficacy of vitamin K in this setting remains uncertain. This...

  • Article
  • Open Access
547 Views
23 Pages

Temporal Evolution of the Profile of Patients Hospitalized with Heart Failure (2000–2022)

  • Teresa Seoane-Pillado,
  • Roi Suárez-Gil,
  • Sonia Pértega-Díaz,
  • Juan Carlos Piñeiro-Fernández,
  • Elena Rodriguez-Ameijeiras and
  • Emilio Casariego-Vales

16 October 2025

Background: The clinical characteristics of patients who have a first episode of congestive heart failure (CHF) may have changed in recent years. Methods: A retrospective cohort study was performed on 19,796 patients discharged from medical departmen...

  • Article
  • Open Access
781 Views
8 Pages

Impact of a Nutrition Protocol on Vitamin D Supplementation in a Pediatric Intensive Care Unit: A Retrospective Cohort Study

  • Maria Pérez Marin,
  • Vivianne Chanez,
  • Guillaume Maitre,
  • Laurence Boillat,
  • Frida Rizzati,
  • Pauline Lauwers and
  • Maria-Helena Perez

13 October 2025

Background: Vitamin D deficiency (VDD) is highly prevalent in pediatric critically ill patients and is a potentially modifiable risk factor during critical illness. There are no established national or international recommendations for vitamin D supp...

  • Article
  • Open Access
1,019 Views
13 Pages

Corticosteroid Use and Recurrence Risk Factors in Granulomatous Mastitis: A 17-Year Saudi Arabian Cohort Study—Steroids in Granulomatous Mastitis

  • Shoag J. Albugami,
  • Rema F. AlRasheed,
  • Hussam A. Alharbi,
  • Sarah S. Alobaid,
  • Hawazin S. Alqahtani,
  • Mays N. Alharbi,
  • Eyad AlKharashi and
  • Khalid Alhajri

Background: Granulomatous mastitis (GM) is a rare, chronic inflammatory breast condition with poorly understood etiology and variable clinical presentation. The efficacy of corticosteroid therapy in reducing recurrence remains controversial, particul...

  • Article
  • Open Access
1,151 Views
13 Pages

Asthma Hospitalizations in Children Before and After COVID-19: Insights from Northern Colombia

  • Moisés Árquez-Mendoza,
  • Karen Franco-Valencia,
  • Marco Anaya-Romero,
  • Maria Acevedo-Cerchiaro,
  • Stacey Fragozo-Messino,
  • Deiby Luz Pertuz-Guzman and
  • Jaime Luna-Carrascal

Background: Pediatric asthma is a multifactorial condition influenced by environmental, biological, and social determinants. The COVID-19 pandemic introduced new variables that may have affected the severity and management of asthma in children and a...

  • Article
  • Open Access
862 Views
12 Pages

Impact of Carotid Artery Tortuosity on Technical Aspects of Endovascular Thrombectomy in a Newly Established Thrombectomy-Capable Stroke Center

  • Katja Lovoković,
  • Vjekoslav Kopačin,
  • Mihael Mišir,
  • Mateo Grigić,
  • Domagoj Matijević,
  • Tatjana Rotim,
  • Domagoj Kretić,
  • Damir Štimac,
  • Anja Tomić and
  • Tajana Turk
  • + 1 author

Background/Objectives: Blood vessel tortuosity can complicate endovascular procedures such as endovascular thrombectomy in acute ischemic stroke. This study aimed to assess the morphometric characteristics of carotid arteries and investigate the asso...

  • Review
  • Open Access
3,114 Views
15 Pages

Treating Temporomandibular Disorders Through Orthodontics: A Scoping Review of Evidence, Gaps, and Clinical Guidance

  • Man Hung,
  • Jacob Daniel Gardner,
  • Samantha Lee,
  • Wendy C. Birmingham,
  • Richard M. Stevens,
  • Connor Schwartz,
  • Nader Karimi and
  • Amir Mohajeri

30 September 2025

Introduction: Evidence on orthodontic interventions for temporomandibular disorders (TMD) is fragmented and inconclusive, creating a gap in guidance for clinical decision-making. This study addresses that gap by evaluating current knowledge on these...

  • Article
  • Open Access
1,082 Views
17 Pages

28 September 2025

Background: In an era of unprecedented technology adoption in healthcare, it is imperative to understand and predict factors influencing users’ perspective. This study employs a risk-integrated technology acceptance model aiming to identify the...

  • Systematic Review
  • Open Access
2,351 Views
14 Pages

The Effects of Physical Exercise on Depression and Anxiety in Cancer Patients: A Systematic Review

  • Giacomo Farì,
  • Annatonia Fai,
  • Francesco Quarta,
  • Morena Pitruzzella,
  • Cristiano Sconza,
  • Matteo Luigi Giuseppe Leoni,
  • Giustino Varrassi,
  • Marco Filipponi,
  • Giuseppe Rollo and
  • Andrea Bernetti
  • + 1 author

28 September 2025

Background: Depression affects around 280 million people globally and is one of the main causes of disability. Among people with cancer, depression and anxiety affect 20–25%, significantly reducing quality of life, adherence to treatments, and...

  • Article
  • Open Access
890 Views
14 Pages

Vitamin D and Postoperative Recovery in Elderly Ribeirinhos—Riverside Amazon Communities with Femur Fractures

  • Elca Silvania da Silva Abreu,
  • Caroline Oliveira dos Anjos,
  • Zafirah Muhammad Rahman,
  • Renata Miyabara,
  • Ovidiu Constantin Baltatu and
  • Luciana Aparecida Campos

28 September 2025

Background/Objectives: Vitamin D deficiency is prevalent in elderly populations and may impact surgical recovery. Despite the equatorial location, vitamin D insufficiency affects many elderly Ribeirinhos in the Brazilian Amazon. This study investigat...

  • Review
  • Open Access
1 Citations
6,082 Views
36 Pages

Serum Sickness-Like Reaction: A Narrative Review of Epidemiology, Immunopathogenesis, Diagnostic Challenges, and Therapeutic Approaches

  • Christodoulos Chatzigrigoriadis,
  • Emmanouil Koufopoulos,
  • Prodromos Avramidis,
  • Ioannis Erginousakis,
  • Vasiliki Karakoida,
  • Theofanis Papadopoulos,
  • Despoina Sperdouli,
  • Myrsini-Eirini Tachliabouri,
  • Kyriakos Vilanakis and
  • Doxakis Anestakis
  • + 5 authors

26 September 2025

Serum sickness-like reaction (SSLR) is a rare immune-mediated condition that typically affects the skin and joints after exposure to certain drugs, infections, or vaccines. Although it shares clinical similarities with serum sickness (SS), SSLR diffe...

  • Article
  • Open Access
1,014 Views
17 Pages

Clinical and Histopathological Correlates of Endometrial Proliferative Lesions in Perimenopausal Women: A Retrospective Study with Internal Validation of a Risk Model

  • Anca Daniela Brăila,
  • Viorica Tudor,
  • Cristian-Viorel Poalelungi,
  • Constantin Marian Damian,
  • Claudia Florina Bogdan-Andreescu,
  • Alexandru Burcea,
  • Andreea-Mariana Bănățeanu,
  • Emin Cadar and
  • Cristina-Crenguţa Albu

26 September 2025

Background: Endometrial proliferative lesions are common in the menopausal transition and carry a measurable risk of carcinoma. Early risk stratification may guide evaluation and follow-up. Methods: We performed a single-center retrospective study of...

  • Article
  • Open Access
957 Views
12 Pages

Gender-Pain Questionnaire: Internal Validation of a Scale for Assessing the Influence of Chronic Pain Experience on Gender Identity and Roles

  • Ana M. Peiró,
  • Noelia Serrano-Gadea,
  • Daniel García-Torres,
  • María Teresa Ruiz-Cantero and
  • Virtudes Pérez-Jover

25 September 2025

Background/Objectives: Gender (roles as household load and job strain, and identity) represent an effect modifier of the interference between pain experience and sex because it is different between men and women. This study validates a new scale deve...

  • Article
  • Open Access
2,052 Views
11 Pages

Hyperkalemia in Heart Failure with Reduced Ejection Fraction Patients Treated with Sacubitril/Valsartan: Experience from a Tertiary Cardiac Center in Riyadh, Saudi Arabia

  • Sarah M. Alyousif,
  • Naif K. Alaqil,
  • Mohamad Abdelshafy,
  • Turki Alasmari,
  • Naif H. Alqadhy,
  • Nawaf S. Alzahrani,
  • Mohammed A. Alhefdhi,
  • Nawaf A. Alqahtani,
  • Aamir Omair and
  • Ahmed Alsaileek

24 September 2025

Background/Objectives: Heart failure with reduced ejection fraction (HFrEF) remains a major global health burden. Sacubitril/valsartan, an angiotensin receptor neprilysin inhibitor (ARNI), improves outcomes in HFrEF but may cause hyperkalemia. Method...

  • Article
  • Open Access
1,031 Views
18 Pages

Bridging Gaps in Occupational Respiratory Disease Management: A Comparative Survey of Pulmonologists and Occupational Physicians in Italy

  • Alessandra Tortorella,
  • Alessio Marinelli,
  • Luigi De Maria,
  • Silvano Dragonieri,
  • Giuseppe Del Vecchio,
  • Vitaliano Nicola Quaranta,
  • Andrea Portacci,
  • Giovanna Elisiana Carpagnano and
  • Luigi Vimercati

24 September 2025

Background: Themanagement of occupational respiratory diseases (ORDs) requires a multidisciplinary approach, yet collaboration between pulmonologists and occupational physicians is often fragmented, potentially compromising patient outcomes. This stu...

  • Review
  • Open Access
3 Citations
3,566 Views
30 Pages

Cancer Pain Is Not One-Size-Fits-All: Evolving from Tradition to Precision

  • Nidha Shapoo,
  • Abdul Rehman,
  • Carlos Izaguirre-Rojas,
  • Vladimir Gotlieb and
  • Noella Boma

23 September 2025

Cancer pain remains a significant challenge in oncology, profoundly affecting patients’ quality of life, function, and prognosis. Historically under-recognized and managed with a uniform, opioid-centric approach, cancer pain was often inadequat...

  • Article
  • Open Access
2,663 Views
18 Pages

Safety and Efficacy of Citrate Anticoagulation in Therapeutic Plasma Exchange: A Clinical Study

  • Ciprian Gîndac,
  • Tamara Mirela Poroșnicu,
  • Nilima Rajpal Kundnani,
  • Nicoleta Sgăvârdea,
  • Claudiu Rafael Bârsac,
  • Vlad Meche,
  • Adelina Băloi,
  • Laura Alexandra Nussbaum,
  • Ovidiu Horea Bedreag and
  • Marius Păpurică
  • + 1 author

23 September 2025

Introduction: TPE (therapeutic plasma exchange) has proven to be an extremely effective treatment for a range of conditions, especially over the past 20 years. Anticoagulation with heparin is currently the accepted recommendation for therapeutic plas...

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Clin. Pract. - ISSN 2039-7283