Clinics and Practice, Volume 15, Issue 10
2025 October - 19 articles
Cover Story: Serum sickness-like reaction (SSLR) is an uncommon immune system disorder characterized by the classic triad of fever, rash, and articular involvement following recent exposure to various triggers, including infectious diseases (predominantly viral), drugs (mostly antibiotics and monoclonal antibodies), and, less frequently, vaccines. Although the clinical presentation and management of SSLR resemble those of serum sickness, the two conditions differ in etiology, mechanisms, and pathology. The lack of high-quality evidence and formal guidelines limits current understanding of the immunopathology and management of SSLR. This narrative review summarizes available data on the epidemiology, pathophysiology, clinical features, diagnosis, and treatment of SSLR, and highlights the need for further research to clarify unresolved issues. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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