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Thalassemia Reports
Volume 7
Issue 1
10.4081/thal.2017.7090
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Thalassemia Reports is published by MDPI from Volume 12 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Spontaneous Fertility in a Male Thalassemic Patient after Allogeneic Hematopoietic Cell Transplantation

by
Nicoletta Iacovidou
1,
Maria Kollia
1,
Emmeleia Nana
1,
Theodora Boutsikou
1,
Christos Savvidis
2,
Antonis Kattamis
3,
Dimitra Kyriakopoulou
3 and
Vassilis Ladis
3,*
1
Department of Neonatology, National and Kapodistrian University of Athens, Aretaieion Hospital, Athens, Greece
2
Department of Endocrinology and Metabolism, Hippocration General Hospital of Athens, Athens, Greece
3
Thalassemia Unit, Division of Pediatric Hematology-Oncology, First Department of Pediatrics, National and Kapodistrian University of Athens, Agia Sofia Children’s Hospital, Papadiamantopoulou and Levadias Str., Goudi 11527, Athens, Greece
*
Author to whom correspondence should be addressed.
Thalass. Rep. 2017, 7(1), 7090; https://doi.org/10.4081/thal.2017.7090
Submission received: 21 September 2017 / Revised: 11 October 2017 / Accepted: 20 October 2017 / Published: 3 November 2017

Abstract

Patients with thalassemia major who received allogeneic hematopoietic cell transplantation are at increased risk of gonadal insufficiency and reduced fertility due to the toxicity of both the transfusional iron overload and the gonadotoxic effects of drugs used in the conditioning regimen. We present a case of an ex-thalassemic patient with spontaneous recovery of spermatogenesis that fathered a healthy, term male neonate. Maternal hemoglobin electrophoresis was within normal limits. At the age of 9.5 years the patient underwent hematopoietic cell transplantation. The conditioning therapy included busulfan (16 mg/kg) and cyclophosphamide (200 mg/kg). No irradiation was administered. Thirty-two days after the hematopoietic cell transplantation the patient developed acute graft-versus-host disease needing long-term treatment with methylprednisolone, cyclosporine and immunoglobulin. Although consecutive semen analyses after the hematopoietic cell transplantation revealed azoospermia, the last semen analysis before conception, at the age of 33 years, was improved and normal follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (Te) levels were detected. The current pregnancy was the result of physical conception. In this case, it seems that thalassemia major along with the respective treatment prior to- and posthematopoietic cell transplantation did not irreparably impair spermatogenesis, probably due to the pre-pubertal time frame they were implemented.
Keywords: thalassemia; allogeneic hematopoietic cell transplantation; male fertility thalassemia; allogeneic hematopoietic cell transplantation; male fertility

Share and Cite

MDPI and ACS Style

Iacovidou, N.; Kollia, M.; Nana, E.; Boutsikou, T.; Savvidis, C.; Kattamis, A.; Kyriakopoulou, D.; Ladis, V. Spontaneous Fertility in a Male Thalassemic Patient after Allogeneic Hematopoietic Cell Transplantation. Thalass. Rep. 2017, 7, 7090. https://doi.org/10.4081/thal.2017.7090

AMA Style

Iacovidou N, Kollia M, Nana E, Boutsikou T, Savvidis C, Kattamis A, Kyriakopoulou D, Ladis V. Spontaneous Fertility in a Male Thalassemic Patient after Allogeneic Hematopoietic Cell Transplantation. Thalassemia Reports. 2017; 7(1):7090. https://doi.org/10.4081/thal.2017.7090

Chicago/Turabian Style

Iacovidou, Nicoletta, Maria Kollia, Emmeleia Nana, Theodora Boutsikou, Christos Savvidis, Antonis Kattamis, Dimitra Kyriakopoulou, and Vassilis Ladis. 2017. "Spontaneous Fertility in a Male Thalassemic Patient after Allogeneic Hematopoietic Cell Transplantation" Thalassemia Reports 7, no. 1: 7090. https://doi.org/10.4081/thal.2017.7090

APA Style

Iacovidou, N., Kollia, M., Nana, E., Boutsikou, T., Savvidis, C., Kattamis, A., Kyriakopoulou, D., & Ladis, V. (2017). Spontaneous Fertility in a Male Thalassemic Patient after Allogeneic Hematopoietic Cell Transplantation. Thalassemia Reports, 7(1), 7090. https://doi.org/10.4081/thal.2017.7090

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