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Thalassemia Reports
Volume 4
Issue 2
10.4081/thal.2014.1967
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Thalassemia Reports is published by MDPI from Volume 12 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Raman Spectroscopy Technology to Monitor the Carotenoids in Skin of Thalassemia Patients: A Novel Non-Invasive Tool Relating Oxidative Stress with Iron Burden

by
Anna Perrone
1,
Luisa Tesoriere
1,
Anna Maria Pintaudi
1,
Alessandro Attanzio
1,
Paolo Rigano
2,
Aurelio Maggio
2 and
Maria Antonietta Livrea
1,*
1
Dipartimento STEBICEF, Università di Palermo, Palermo, Italy
2
Divisione di Ematologia e Malattie Rare del Sangue e degli Organi Ematopoietici, Ospedali Riuniti Villa Sofia Cervello, Palermo, Italy
*
Author to whom correspondence should be addressed.
Thalass. Rep. 2014, 4(2), 1967; https://doi.org/10.4081/thal.2014.1967
Submission received: 4 October 2013 / Revised: 26 October 2013 / Accepted: 20 May 2014 / Published: 29 September 2014

Abstract

In this work we approach the relationship between redox state and iron overload by noninvasive instrumental techniques. Intracardiac, liver iron and liver fibrosis have been monitored in transfusion-dependent thalassemia patients by magnetic resonance imaging and hepatic transient elastography examinations. These measurements have been matched with a non-invasive, and yet unexplored in clinical practice, evaluation of body’s oxidative stress through measurement of antioxidant carotenoids in skin, by a spectroscopic method based on Raman technology (RRS). The global body’s antioxidant status results from a balance between the level of antioxidants in cells and body fluids, including blood, and pro-oxidant species endogenously produced or coming from external sources. On this basis, the level of skin carotenoids can be considered a biomarker of the entire antioxidant status. In our work the use of RRS method provided information on the redox state of thalassemia patients, which was correlated with the iron status of the patients. Due to the highly adverse effects of accumulated iron, the novel, simple, non-invasive RRS to monitor dermal carotenoids with high compliance of the patients may be a useful tool for the management of thalassemia patients.
Keywords: Raman spectroscopy technology; skin carotenoids; thalassemia; oxidative stress Raman spectroscopy technology; skin carotenoids; thalassemia; oxidative stress

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MDPI and ACS Style

Perrone, A.; Tesoriere, L.; Pintaudi, A.M.; Attanzio, A.; Rigano, P.; Maggio, A.; Livrea, M.A. Raman Spectroscopy Technology to Monitor the Carotenoids in Skin of Thalassemia Patients: A Novel Non-Invasive Tool Relating Oxidative Stress with Iron Burden. Thalass. Rep. 2014, 4, 1967. https://doi.org/10.4081/thal.2014.1967

AMA Style

Perrone A, Tesoriere L, Pintaudi AM, Attanzio A, Rigano P, Maggio A, Livrea MA. Raman Spectroscopy Technology to Monitor the Carotenoids in Skin of Thalassemia Patients: A Novel Non-Invasive Tool Relating Oxidative Stress with Iron Burden. Thalassemia Reports. 2014; 4(2):1967. https://doi.org/10.4081/thal.2014.1967

Chicago/Turabian Style

Perrone, Anna, Luisa Tesoriere, Anna Maria Pintaudi, Alessandro Attanzio, Paolo Rigano, Aurelio Maggio, and Maria Antonietta Livrea. 2014. "Raman Spectroscopy Technology to Monitor the Carotenoids in Skin of Thalassemia Patients: A Novel Non-Invasive Tool Relating Oxidative Stress with Iron Burden" Thalassemia Reports 4, no. 2: 1967. https://doi.org/10.4081/thal.2014.1967

APA Style

Perrone, A., Tesoriere, L., Pintaudi, A. M., Attanzio, A., Rigano, P., Maggio, A., & Livrea, M. A. (2014). Raman Spectroscopy Technology to Monitor the Carotenoids in Skin of Thalassemia Patients: A Novel Non-Invasive Tool Relating Oxidative Stress with Iron Burden. Thalassemia Reports, 4(2), 1967. https://doi.org/10.4081/thal.2014.1967

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