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Pediatric Reports
Volume 6
Issue 3
10.4081/pr.2014.5532
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Article

Electroencephalogram and Magnetic Resonance Imaging Comparison as a Predicting Factor for Neurodevelopmental Outcome in Hypoxic Ischemic Encephalopathy Infant Treated with Hypothermia

by
Francesca Del Balzo
,
Stella Maiolo
,
Paola Papoff
,
Luigi Giannini
,
Corrado Moretti
,
Enrico Properzi
and
Alberto Spalice
*
Division of Child Neurology, Department of Pediatrics, La Sapienza University, Rome, Italy
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2014, 6(3), 5532; https://doi.org/10.4081/pr.2014.5532
Submission received: 27 June 2014 / Revised: 27 June 2014 / Accepted: 11 August 2014 / Published: 1 October 2014

Abstract

Hypoxic-ischemic encephalopathy (HIE) is an important cause of acute neurological damage in newborns at (or near) term. Several trials in recent years have shown that moderate hypothermia by total body cooling or selective head is an effective intervention to reduce mortality and major disability in infants survived a perinatal hypoxic-ischemic attack. Follow-up in these patients is very important to establish neurodevelopmental outcome, and specific markers can lead us to detect predicting sign for good or poor outcome. We reported a few cases of newborn with HIE treated with hypothermia, in whom the comparison between electroencephalogram (EEG) and magnetic resonance imaging (MRI) represents the first marker for neurodevelopment outcome prediction. The continuous EEG monitoring showed a depressed EEG activity with diffuse burst depression in 7 patients. No epileptic abnormalities were registered. In 10 out of 20 patients no abnormalities of the background activity and no epileptic abnormalities were observed. We found that a depressed EEG activity during the first 72 h of life and a diffused alteration of basal ganglia at MRI were correlated with a poor neurodevelopmental outcome at 18 months of follow-up.
Keywords: hypothermia; neonates; magnetic resonance imaging; long term; electroencephalogram monitoring hypothermia; neonates; magnetic resonance imaging; long term; electroencephalogram monitoring

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MDPI and ACS Style

Del Balzo, F.; Maiolo, S.; Papoff, P.; Giannini, L.; Moretti, C.; Properzi, E.; Spalice, A. Electroencephalogram and Magnetic Resonance Imaging Comparison as a Predicting Factor for Neurodevelopmental Outcome in Hypoxic Ischemic Encephalopathy Infant Treated with Hypothermia. Pediatr. Rep. 2014, 6, 5532. https://doi.org/10.4081/pr.2014.5532

AMA Style

Del Balzo F, Maiolo S, Papoff P, Giannini L, Moretti C, Properzi E, Spalice A. Electroencephalogram and Magnetic Resonance Imaging Comparison as a Predicting Factor for Neurodevelopmental Outcome in Hypoxic Ischemic Encephalopathy Infant Treated with Hypothermia. Pediatric Reports. 2014; 6(3):5532. https://doi.org/10.4081/pr.2014.5532

Chicago/Turabian Style

Del Balzo, Francesca, Stella Maiolo, Paola Papoff, Luigi Giannini, Corrado Moretti, Enrico Properzi, and Alberto Spalice. 2014. "Electroencephalogram and Magnetic Resonance Imaging Comparison as a Predicting Factor for Neurodevelopmental Outcome in Hypoxic Ischemic Encephalopathy Infant Treated with Hypothermia" Pediatric Reports 6, no. 3: 5532. https://doi.org/10.4081/pr.2014.5532

APA Style

Del Balzo, F., Maiolo, S., Papoff, P., Giannini, L., Moretti, C., Properzi, E., & Spalice, A. (2014). Electroencephalogram and Magnetic Resonance Imaging Comparison as a Predicting Factor for Neurodevelopmental Outcome in Hypoxic Ischemic Encephalopathy Infant Treated with Hypothermia. Pediatric Reports, 6(3), 5532. https://doi.org/10.4081/pr.2014.5532

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