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Pediatric Reports
Volume 11
Issue 3
10.4081/pr.2019.8166
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Case Report

Amiodarone-Induced Thyrotoxicosis in a Pediatric Patient: A Rare and Demanding Clinical Case

by
Sofia Oliveira
1,2,3,4,*,
Bernardo Marques
1,5,
Sérgio Laranjo
6 and
Lurdes Lopes
1
1
Unit of Pediatric Endocrinology, Centro Hospitalar de Lisboa Central, Lisbon; Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2
Unit of Pediatric Endocrinology, Centro Hospitalar de Lisboa Central, Lisbon; Department of Endocrinology, Instituto Português de Oncologia de Coimbra Francisco Gentil, Coimbra
3
Department of Pediatric Cardiology, Centro Hospitalar de Lisboa Central, Lisbon
4
Unit of Pediatric Endocrinology, Centro Hospitalar de Lisboa Central, Lisbon
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2019, 11(3), 8166; https://doi.org/10.4081/pr.2019.8166
Submission received: 3 May 2019 / Revised: 30 July 2019 / Accepted: 31 July 2019 / Published: 24 September 2019

Abstract

Thyroid dysfunction is one of the most common adverse effects of amiodarone therapy, ranging from subclinical changes to overt clinical thyrotoxicosis (AIT) and/or hypothyroidism. Due to its heterogeneity, AIT lasts as a defiant entity, leading to a thorny treatment course, particularly in pediatrics. AIT can be classified as either type 1, type 2 or mixed form based on its pathophysiology. Differentiating between the main AIT subtypes is quite relevant, since there is specific treatment for both, however, this distinction may be difficult in clinical practice. We describe a rare case of AIT in a pediatric patient, with an uncommon congenital cardiac malformation, that started amiodarone therapy due to paroxysmal supraventricular tachycardia. AIT was reported 26 months after drug onset, with a sudden and explosive emerging. This case highlights the current AIT management challenges on the highdemanding pediatric field pursuing, ultimately, an enhanced patient´'s care.
Keywords: thyrotoxicosis; amiodarone; adolescence thyrotoxicosis; amiodarone; adolescence

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MDPI and ACS Style

Oliveira, S.; Marques, B.; Laranjo, S.; Lopes, L. Amiodarone-Induced Thyrotoxicosis in a Pediatric Patient: A Rare and Demanding Clinical Case. Pediatr. Rep. 2019, 11, 8166. https://doi.org/10.4081/pr.2019.8166

AMA Style

Oliveira S, Marques B, Laranjo S, Lopes L. Amiodarone-Induced Thyrotoxicosis in a Pediatric Patient: A Rare and Demanding Clinical Case. Pediatric Reports. 2019; 11(3):8166. https://doi.org/10.4081/pr.2019.8166

Chicago/Turabian Style

Oliveira, Sofia, Bernardo Marques, Sérgio Laranjo, and Lurdes Lopes. 2019. "Amiodarone-Induced Thyrotoxicosis in a Pediatric Patient: A Rare and Demanding Clinical Case" Pediatric Reports 11, no. 3: 8166. https://doi.org/10.4081/pr.2019.8166

APA Style

Oliveira, S., Marques, B., Laranjo, S., & Lopes, L. (2019). Amiodarone-Induced Thyrotoxicosis in a Pediatric Patient: A Rare and Demanding Clinical Case. Pediatric Reports, 11(3), 8166. https://doi.org/10.4081/pr.2019.8166

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