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Microbiology Research
Volume 8
Issue 1
10.4081/mr.2017.6963
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Article

In Vitro Antitrypanosomal Potential of Chloroform Leaf Extract of Punica granatum L. on Trypanosoma brucei brucei and Trypanosoma evansi

by
Muhammad Muhsin Fathuddin
1,* and
Helen Ileigo Inabo
2
1
Department of Microbiology, Kaduna State University, Kaduna, Nigeria
2
Department of Microbiology, Faculty of Science, Ahmadu Bello University, Zaria, Nigeria
*
Author to whom correspondence should be addressed.
Microbiol. Res. 2017, 8(1), 6963; https://doi.org/10.4081/mr.2017.6963
Submission received: 12 November 2016 / Revised: 12 March 2017 / Accepted: 30 March 2017 / Published: 15 September 2017

Abstract

The plant Pomegranate (Punica granatum Linn.) selected for this study is native to the region of Eurasia. The objective of this study was to evaluate the antitrypanosomal potential of the plant against Trypanosoma brucei brucei (T.b. brucei) and Trypanosoma evansi (T. evansi). Similarly, the parasites used for this study have two entirely different modes of transmission that is Cyclical Transmission (T.b. brucei) and Mechanical Transmission (T. evansi). The chloroform extract of Punica granatum (P. granatum) was analysed in vitro for trypanocidal activity against T.b. brucei and T. evansi at concentrations of 100 mg/mL, 50 mg/mL, 25 mg/mL, 12.5 mg/mL and 6.25 mg/mL. The chloroform extracts of P. granatum had trypanocidal activity against T. evansi and was inactive against T.b. brucei. These findings suggest that the mode of transmission may have an effect on the parasite-drug reaction and the possible use of the chloroform extract of P. granatum in the management of trypanosomiasis due to T. evansi which may require further elucidation.
Keywords: antitrypanosomal activity; in vitro; Trypanosoma brucei brucei; Trypanosoma evansi; chloroform; Punica granatum antitrypanosomal activity; in vitro; Trypanosoma brucei brucei; Trypanosoma evansi; chloroform; Punica granatum

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MDPI and ACS Style

Fathuddin, M.M.; Inabo, H.I. In Vitro Antitrypanosomal Potential of Chloroform Leaf Extract of Punica granatum L. on Trypanosoma brucei brucei and Trypanosoma evansi. Microbiol. Res. 2017, 8, 6963. https://doi.org/10.4081/mr.2017.6963

AMA Style

Fathuddin MM, Inabo HI. In Vitro Antitrypanosomal Potential of Chloroform Leaf Extract of Punica granatum L. on Trypanosoma brucei brucei and Trypanosoma evansi. Microbiology Research. 2017; 8(1):6963. https://doi.org/10.4081/mr.2017.6963

Chicago/Turabian Style

Fathuddin, Muhammad Muhsin, and Helen Ileigo Inabo. 2017. "In Vitro Antitrypanosomal Potential of Chloroform Leaf Extract of Punica granatum L. on Trypanosoma brucei brucei and Trypanosoma evansi" Microbiology Research 8, no. 1: 6963. https://doi.org/10.4081/mr.2017.6963

APA Style

Fathuddin, M. M., & Inabo, H. I. (2017). In Vitro Antitrypanosomal Potential of Chloroform Leaf Extract of Punica granatum L. on Trypanosoma brucei brucei and Trypanosoma evansi. Microbiology Research, 8(1), 6963. https://doi.org/10.4081/mr.2017.6963

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