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Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
Article

The Effects of Fasting during Ramadan on the Concentration of Serotonin, Dopamine, Brainderived Neurotrophic Factor and Nerve Growth Factor

Biochemistry Department, Shahid Beheshti University of Medical Sciences,Tehran, Iran
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Author to whom correspondence should be addressed.
Neurol. Int. 2017, 9(2), 29-33; https://doi.org/10.4081/ni.2017.7043
Received: 11 January 2017 / Revised: 24 April 2017 / Accepted: 17 May 2017 / Published: 23 June 2017
Neurotransmitters and neurotrophic factors are signaling molecules that play a crucial role in cell proliferation, differentiation, survival and functions of neurons. It is believed that caloric restriction could help the health of the nervous system by affecting the synthesis of neurotrophins and neurotransmitter and oxygen radical metabolism. The objective was to investigate the plasma levels of serotonin, dopamine, brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) in 29 healthy fasted subjects (22 women and 7 men) during the month of fasting in Ramadan. The levels of these factors were measured (using ELISA method) three times, 2 days before the fasting month as a control, on the 14th and 29th day of Ramadan as test groups. In addition, these factors were investigated in the group of women only. According to our investigation, the plasma levels of serotonin, BDNF and NGF were significantly increased during fasting month of Ramadan. In detail, the levels of these factors were increased in 14th and 29th day test groups compared to controls (P<0.05). Moreover, these levels were significantly increased on the 29th day compared to the 14th day test groups, but there were no differences between dopamine levels in all groups. Furthermore, the results obtained in women’s groups were the same as those obtained in previous groups. Our findings suggest that plasma levels of serotonin, BDNF and NGF were significantly increased during fasting month of Ramadan.
Keywords: Caloric restriction; Serotonin; Dopamine; BDNF; NGF Caloric restriction; Serotonin; Dopamine; BDNF; NGF
MDPI and ACS Style

Bastani, A.; Rajabi, S.; Kianimarkani, F. The Effects of Fasting during Ramadan on the Concentration of Serotonin, Dopamine, Brainderived Neurotrophic Factor and Nerve Growth Factor. Neurol. Int. 2017, 9, 29-33. https://doi.org/10.4081/ni.2017.7043

AMA Style

Bastani A, Rajabi S, Kianimarkani F. The Effects of Fasting during Ramadan on the Concentration of Serotonin, Dopamine, Brainderived Neurotrophic Factor and Nerve Growth Factor. Neurology International. 2017; 9(2):29-33. https://doi.org/10.4081/ni.2017.7043

Chicago/Turabian Style

Bastani, Abdolhossein, Sadegh Rajabi, and Fatemeh Kianimarkani. 2017. "The Effects of Fasting during Ramadan on the Concentration of Serotonin, Dopamine, Brainderived Neurotrophic Factor and Nerve Growth Factor" Neurology International 9, no. 2: 29-33. https://doi.org/10.4081/ni.2017.7043

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