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Neurology International
Volume 6
Issue 3
10.4081/ni.2014.5395
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Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Brief Report

Aquaporin-4 Immuneglobulin G Testing in 36 Consecutive Jamaican Patients with Inflammatory Central Nervous System Demyelinating Disease

by
Sherri Sandy
1,
Sean J. Pittock
2,*,
Terence A.R. Seemungal
1 and
Amza Ali
3
1
Department of Clinical Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago
2
Department of Neurology, Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA
3
Kingston Public and University Hospital of the West Indies, Mona, Jamaica
*
Author to whom correspondence should be addressed.
Neurol. Int. 2014, 6(3), 5395; https://doi.org/10.4081/ni.2014.5395
Submission received: 18 March 2014 / Revised: 28 May 2014 / Accepted: 5 June 2014 / Published: 8 August 2014

Abstract

Epidemiological studies of neuromyelitis optica (NMO) in Jamaica are lacking. Here we reviewed the clinical records of 700 patients undergoing neurological evaluation at the Kingston Public Hospital, the largest tertiary institution in Jamaica over a 4 month period. We investigated the diagnostic utility of Aquaporin-4 ImmuneglobulinG (AQP4-IgG) testing in 36 consecutive patients with a diagnosis of an inflammatory demyelinating disorder (IDD) of the central nervous system (CNS). Patients were classified into 3 categories: i) NMO, n=10; ii) multiple sclerosis (MS), n=14 and iii) unclassified IDD (n=12). All sera were tested for AQP-IgG status by cell binding assay (Euroimmun). No MS cases were positive. Ninety per cent of NMO cases were positive. Four of 12 patients with unclassified IDD tested positive for AQP4-IgG. AQP4-IgG seropositivity was associated with a lower socioeconomic status, higher EDSS (P=0.04) and lower pulmonary function than the seronegative cases (P=0.007). Aquaporin-4 autoimmunity may account for a significant proportion of Jamaican CNS IDDs.
Keywords: AQP4/NMO-IgG; neuroimmunology; neuromyelitis optica; multiple sclerosis; tropical neurology AQP4/NMO-IgG; neuroimmunology; neuromyelitis optica; multiple sclerosis; tropical neurology

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MDPI and ACS Style

Sandy, S.; Pittock, S.J.; Seemungal, T.A.R.; Ali, A. Aquaporin-4 Immuneglobulin G Testing in 36 Consecutive Jamaican Patients with Inflammatory Central Nervous System Demyelinating Disease. Neurol. Int. 2014, 6, 5395. https://doi.org/10.4081/ni.2014.5395

AMA Style

Sandy S, Pittock SJ, Seemungal TAR, Ali A. Aquaporin-4 Immuneglobulin G Testing in 36 Consecutive Jamaican Patients with Inflammatory Central Nervous System Demyelinating Disease. Neurology International. 2014; 6(3):5395. https://doi.org/10.4081/ni.2014.5395

Chicago/Turabian Style

Sandy, Sherri, Sean J. Pittock, Terence A.R. Seemungal, and Amza Ali. 2014. "Aquaporin-4 Immuneglobulin G Testing in 36 Consecutive Jamaican Patients with Inflammatory Central Nervous System Demyelinating Disease" Neurology International 6, no. 3: 5395. https://doi.org/10.4081/ni.2014.5395

APA Style

Sandy, S., Pittock, S. J., Seemungal, T. A. R., & Ali, A. (2014). Aquaporin-4 Immuneglobulin G Testing in 36 Consecutive Jamaican Patients with Inflammatory Central Nervous System Demyelinating Disease. Neurology International, 6(3), 5395. https://doi.org/10.4081/ni.2014.5395

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