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Bioavailability of Polyphenol Liposomes: A Challenge Ahead

Chemical, Genetic and Imaging Pharmacology Laboratory (CNRS UMR 8151, INSERM U1022), Faculty of Pharmacy, Paris Descartes University, Sorbonne Paris Cité, Chimie-ParisTech, 4 avenue de l'Observatoire, Paris F-75006, France
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Pharmaceutics 2013, 5(3), 457-471; https://doi.org/10.3390/pharmaceutics5030457
Received: 1 August 2013 / Revised: 29 August 2013 / Accepted: 4 September 2013 / Published: 17 September 2013
(This article belongs to the Special Issue Liposome Technologies)
Dietary polyphenols, including flavonoids, have long been recognized as a source of important molecules involved in the prevention of several diseases, including cancer. However, because of their poor bioavailability, polyphenols remain difficult to be employed clinically. Over the past few years, a renewed interest has been devoted to the use of liposomes as carriers aimed at increasing the bioavailability and, hence, the therapeutic benefits of polyphenols. In this paper, we review the causes of the poor bioavailability of polyphenols and concentrate on their liposomal formulations, which offer a means of improving their pharmacokinetics and pharmacodynamics. The problems linked to their development and their potential therapeutic advantages are reviewed. Future directions for liposomal polyphenol development are suggested. View Full-Text
Keywords: polyphenols; flavonoids; liposomes; lipid polyphenol interaction; bioavailability polyphenols; flavonoids; liposomes; lipid polyphenol interaction; bioavailability
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MDPI and ACS Style

Mignet, N.; Seguin, J.; Chabot, G.G. Bioavailability of Polyphenol Liposomes: A Challenge Ahead. Pharmaceutics 2013, 5, 457-471. https://doi.org/10.3390/pharmaceutics5030457

AMA Style

Mignet N, Seguin J, Chabot GG. Bioavailability of Polyphenol Liposomes: A Challenge Ahead. Pharmaceutics. 2013; 5(3):457-471. https://doi.org/10.3390/pharmaceutics5030457

Chicago/Turabian Style

Mignet, Nathalie, Johanne Seguin, and Guy G. Chabot. 2013. "Bioavailability of Polyphenol Liposomes: A Challenge Ahead" Pharmaceutics 5, no. 3: 457-471. https://doi.org/10.3390/pharmaceutics5030457

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