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Article
Peer-Review Record

Antimutagenicity and Antioxidant Activity of Castanea sativa Mill. Bark Extract

Pharmaceutics 2023, 15(10), 2465; https://doi.org/10.3390/pharmaceutics15102465
by Sofia Gasperini 1, Giulia Greco 2, Sabrina Angelini 1, Patrizia Hrelia 1, Carmela Fimognari 3,* and Monia Lenzi 1
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3:
Pharmaceutics 2023, 15(10), 2465; https://doi.org/10.3390/pharmaceutics15102465
Submission received: 8 September 2023 / Revised: 29 September 2023 / Accepted: 11 October 2023 / Published: 14 October 2023
(This article belongs to the Special Issue Natural Products for Anticancer Application)

Round 1

Reviewer 1 Report


Comments for author File: Comments.pdf


Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The authors in the paper titled “Antimutagenic and antioxidant potential of Castanea sativa Mill. Bark extract‚‚ investigate the ability of CSM bark extract to exert an antimutagenic activity, thus inhibiting the earlier phases of the carcinogenic process. I recommend the paper for publishing after some minor revisions.


Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 3 Report

The manuscript is written very solidly and contains valuable data. The authors could only mention the contents of the individual compounds in the extract (Table 1 in Reference 12). Is anything known about the antimutagenic activity of castalin, vescalin, castalagin, vescalagin? The authors only discuss the activity of ellagic and gallic acids.

The histograms should be of better quality, especially the axis descriptions.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

Congratulations on your manuscript. 

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