Translational Value of the Transdermal Administration of Bergamot Essential Oil and of Its Fractions
Abstract
:1. Introduction
2. Materials and Methods
2.1. Reagents
2.2. Phytocomplexes and Components
2.3. Animals
2.4. Pain Model
2.5. Experimental Design
2.6. Statistical Analysis
3. Results
3.1. Analgesic Efficacy of the Transdermal Topical Treatment with BEO on Formalin-Induced Licking/Biting Biphasic Nocifensive Behavior
3.2. Analgesic Effect of BEO, DEC and DET Fractions on Formalin Test after Transdermal Administration
3.3. Effects of the Transdermal Administration of d-limonene, Linalool, and Linalyl Acetate on Formalin-Induced Licking/Biting Behavior
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Scuteri, D.; Rombolà, L.; Crudo, M.; Watanabe, C.; Mizoguchi, H.; Sakurada, S.; Hamamura, K.; Sakurada, T.; Morrone, L.A.; Tonin, P.; et al. Translational Value of the Transdermal Administration of Bergamot Essential Oil and of Its Fractions. Pharmaceutics 2022, 14, 1006. https://doi.org/10.3390/pharmaceutics14051006
Scuteri D, Rombolà L, Crudo M, Watanabe C, Mizoguchi H, Sakurada S, Hamamura K, Sakurada T, Morrone LA, Tonin P, et al. Translational Value of the Transdermal Administration of Bergamot Essential Oil and of Its Fractions. Pharmaceutics. 2022; 14(5):1006. https://doi.org/10.3390/pharmaceutics14051006
Chicago/Turabian StyleScuteri, Damiana, Laura Rombolà, Michele Crudo, Chizuko Watanabe, Hirokazu Mizoguchi, Shinobu Sakurada, Kengo Hamamura, Tsukasa Sakurada, Luigi Antonio Morrone, Paolo Tonin, and et al. 2022. "Translational Value of the Transdermal Administration of Bergamot Essential Oil and of Its Fractions" Pharmaceutics 14, no. 5: 1006. https://doi.org/10.3390/pharmaceutics14051006