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Article

Synthesis and Properties of Targeted Radioisotope Carriers Based on Poly(Acrylic Acid) Nanogels

1
Institute of Applied Radiation Chemistry, Faculty of Chemistry, Lodz University of Technology, Wróblewskiego 15, 93-590 Lodz, Poland
2
National Centre for Nuclear Research, Radioisotope Centre POLATOM, Andrzeja Sołtana 7, 05-400 Otwock, Poland
3
Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Żeromskiego 116, 90-924 Lodz, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Leonard I. Wiebe
Pharmaceutics 2021, 13(8), 1240; https://doi.org/10.3390/pharmaceutics13081240
Received: 3 June 2021 / Revised: 4 August 2021 / Accepted: 6 August 2021 / Published: 11 August 2021
(This article belongs to the Special Issue Nanogels and Nanoparticles for Selective Drug Delivery)
Radiation crosslinking was employed to obtain nanocarriers based on poly(acrylic acid)—PAA—for targeted delivery of radioactive isotopes. These nanocarriers are internally crosslinked hydrophilic macromolecules—nanogels—bearing carboxylic groups to facilitate functionalization. PAA nanogels were conjugated with an engineered bombesin-derivative—oligopeptide combined with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate chelating moiety, aimed to provide selective radioligand transport. 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium (DMTMM) toluene-4-sulfonate was used as the coupling agent. After tests on a model amine—p-toluidine—both commercial and home-synthesized DOTA-bombesin were successfully coupled to the nanogels and the obtained products were characterized. The radiolabeling efficiency of nanocarriers with 177Lu, was chromatographically tested. The results provide a proof of concept for the synthesis of radiation-synthesized nanogel-based radioisotope nanocarriers for theranostic applications. View Full-Text
Keywords: radiation chemistry; biomaterials; poly(acrylic acid); biomedical applications; nanocarriers; nanogels; DMTMM; conjugation; bombesin; DOTA; radioisotopes radiation chemistry; biomaterials; poly(acrylic acid); biomedical applications; nanocarriers; nanogels; DMTMM; conjugation; bombesin; DOTA; radioisotopes
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MDPI and ACS Style

Matusiak, M.; Rurarz, B.P.; Kadłubowski, S.; Wolszczak, M.; Karczmarczyk, U.; Maurin, M.; Kolesińska, B.; Ulański, P. Synthesis and Properties of Targeted Radioisotope Carriers Based on Poly(Acrylic Acid) Nanogels. Pharmaceutics 2021, 13, 1240. https://doi.org/10.3390/pharmaceutics13081240

AMA Style

Matusiak M, Rurarz BP, Kadłubowski S, Wolszczak M, Karczmarczyk U, Maurin M, Kolesińska B, Ulański P. Synthesis and Properties of Targeted Radioisotope Carriers Based on Poly(Acrylic Acid) Nanogels. Pharmaceutics. 2021; 13(8):1240. https://doi.org/10.3390/pharmaceutics13081240

Chicago/Turabian Style

Matusiak, Małgorzata, Beata P. Rurarz, Sławomir Kadłubowski, Marian Wolszczak, Urszula Karczmarczyk, Michał Maurin, Beata Kolesińska, and Piotr Ulański. 2021. "Synthesis and Properties of Targeted Radioisotope Carriers Based on Poly(Acrylic Acid) Nanogels" Pharmaceutics 13, no. 8: 1240. https://doi.org/10.3390/pharmaceutics13081240

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