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Article

Changes in Skin Barrier Function after Repeated Exposition to Phospholipid-Based Surfactants and Sodium Dodecyl Sulfate In Vivo and Corneocyte Surface Analysis by Atomic Force Microscopy

1
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, University of Vienna, 1090 Vienna, Austria
2
Research Platform “Characterisation of Drug Delivery Systems on Skin and Investigation of Involved Mechanisms”, University of Vienna, 1090 Vienna, Austria
3
Serend-ip GmbH, Centre for Nanotechnology, 48149 Münster, Germany
4
Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
Academic Editor: Judith Kuntsche
Pharmaceutics 2021, 13(4), 436; https://doi.org/10.3390/pharmaceutics13040436
Received: 22 February 2021 / Revised: 16 March 2021 / Accepted: 20 March 2021 / Published: 24 March 2021
(This article belongs to the Special Issue Recent Advances in the Use of Phospholipids in Drug Delivery)
(1) Background: The aim of the study was to evaluate the effect of pure lecithins in comparison to a conventional surfactant on skin in vivo. (2) Methods: Physiological skin parameters were evaluated at the beginning and the end of the study (day 1 and day 4) (n = 8, healthy forearm skin) with an Aquaflux®, skin-pH-Meter, Corneometer® and an Epsilon® sensor. Confocal Raman spectroscopy was employed to monitor natural moisturizing factor, urea and water content of the participants’ skin. Tape strips of treated skin sites were taken and the collected corneocytes were subjected to atomic force microscopy. Circular nano objects were counted, and dermal texture indices were determined. (3) Results: Transepidermal water loss was increased, and skin hydration was decreased after treatment with SDS and LPC80. Natural moisturizing factor and urea concentrations within the outermost 10 µm of the stratum corneum were lower than after treatment with S75 or water. Dermal texture indices of skin treated with SDS were higher than skin treated with water (control). (4) Conclusions: Results suggest very good (S75) or good (LPC80) skin-tolerability of lecithin-based surfactants in comparison to SDS and encourage further investigation. View Full-Text
Keywords: surfactants; phospholipids; lecithins; sodium dodecyl sulfate; atomic force microscopy; corneocytes; transepidermal water loss; natural moisturizing factor; skin hydration; dermal texture index surfactants; phospholipids; lecithins; sodium dodecyl sulfate; atomic force microscopy; corneocytes; transepidermal water loss; natural moisturizing factor; skin hydration; dermal texture index
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MDPI and ACS Style

Vater, C.; Apanovic, A.; Riethmüller, C.; Litschauer, B.; Wolzt, M.; Valenta, C.; Klang, V. Changes in Skin Barrier Function after Repeated Exposition to Phospholipid-Based Surfactants and Sodium Dodecyl Sulfate In Vivo and Corneocyte Surface Analysis by Atomic Force Microscopy. Pharmaceutics 2021, 13, 436. https://doi.org/10.3390/pharmaceutics13040436

AMA Style

Vater C, Apanovic A, Riethmüller C, Litschauer B, Wolzt M, Valenta C, Klang V. Changes in Skin Barrier Function after Repeated Exposition to Phospholipid-Based Surfactants and Sodium Dodecyl Sulfate In Vivo and Corneocyte Surface Analysis by Atomic Force Microscopy. Pharmaceutics. 2021; 13(4):436. https://doi.org/10.3390/pharmaceutics13040436

Chicago/Turabian Style

Vater, Claudia, Alexandra Apanovic, Christoph Riethmüller, Brigitte Litschauer, Michael Wolzt, Claudia Valenta, and Victoria Klang. 2021. "Changes in Skin Barrier Function after Repeated Exposition to Phospholipid-Based Surfactants and Sodium Dodecyl Sulfate In Vivo and Corneocyte Surface Analysis by Atomic Force Microscopy" Pharmaceutics 13, no. 4: 436. https://doi.org/10.3390/pharmaceutics13040436

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