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Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics

Institut National de la Recherche Scientifique (INRS), EMT Research Center, Varennes, QC J3X 1S2, Canada
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(5), 211;
Received: 22 March 2019 / Revised: 23 April 2019 / Accepted: 25 April 2019 / Published: 3 May 2019
(This article belongs to the Special Issue Drug Delivery Technology Development in Canada)
Viruses have recently emerged as promising nanomaterials for biotechnological applications. One of the most important applications of viruses is phage display, which has already been employed to identify a broad range of potential therapeutic peptides and antibodies, as well as other biotechnologically relevant polypeptides (including protease inhibitors, minimizing proteins, and cell/organ targeting peptides). Additionally, their high stability, easily modifiable surface, and enormous diversity in shape and size, distinguish viruses from synthetic nanocarriers used for drug delivery. Indeed, several plant and bacterial viruses (e.g., phages) have been investigated and applied as drug carriers. The ability to remove the genetic material within the capsids of some plant viruses and phages produces empty viral-like particles that are replication-deficient and can be loaded with therapeutic agents. This review summarizes the current applications of plant viruses and phages in drug discovery and as drug delivery systems and includes a discussion of the present status of virus-based materials in clinical research, alongside the observed challenges and opportunities. View Full-Text
Keywords: virus; plant; bacteriophage; phage display; drug discovery; encapsulation; drug delivery virus; plant; bacteriophage; phage display; drug discovery; encapsulation; drug delivery
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MDPI and ACS Style

Sokullu, E.; Soleymani Abyaneh, H.; Gauthier, M.A. Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics. Pharmaceutics 2019, 11, 211.

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