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Pharmaceutics 2018, 10(3), 120; https://doi.org/10.3390/pharmaceutics10030120

Hydrogels of Polycationic Acetohydrazone-Modified Phosphorus Dendrimers for Biomedical Applications: Gelation Studies and Nucleic Acid Loading

1
Institute of Chemical Biology and Fundamental Medicine SB RAS, 8, Lavrentiev ave., 630090 Novosibirsk, Russia
2
Ecole des Mines d’Albi Carmaux, Campus Jarlard, 81000 Albi, France
3
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, Université Paris Descartes, PRES Sorbonne Paris Cité, CNRS UMR 8601, 75006 Paris, France
4
Centro de Química da Madeira, MMRG, Universidade da Madeira, 9000-390 Funchal, Portugal
5
Laboratoire de Chimie de Coordination du CNRS, 205, route de Narbonne, BP 44099, 31077 Toulouse CEDEX 04, France
6
LCC-CNRS, Université de Toulouse, CNRS, 31013 Toulouse, France
*
Authors to whom correspondence should be addressed.
Received: 30 June 2018 / Revised: 22 July 2018 / Accepted: 3 August 2018 / Published: 6 August 2018
(This article belongs to the Special Issue Dendrimers in Nanomedical Applications: Update and Future Directions)
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Abstract

In this work, we report the assemblage of hydrogels from phosphorus dendrimers in the presence of biocompatible additives and the study of their interactions with nucleic acids. As precursors for hydrogels, phosphorus dendrimers of generations 1–3 based on the cyclotriphosphazene core and bearing ammonium or pyridinium acetohydrazones (Girard reagents) on the periphery have been synthesized. The gelation was done by the incubation of dendrimer solutions in water or phosphate-buffered saline in the presence of biocompatible additives (glucose, glycine or polyethylene glycol) to form physical gels. Physical properties of gels have been shown to depend on the gelation conditions. Transmission electron microscopy revealed structural units and well-developed network structures of the hydrogels. The hydrogels were shown to bind nucleic acids efficiently. In summary, hydrogels of phosphorus dendrimers represent a useful tool for biomedical applications. View Full-Text
Keywords: phosphorus dendrimers; functionalization; Girard reagents; hydrogels; oligonucleotides phosphorus dendrimers; functionalization; Girard reagents; hydrogels; oligonucleotides
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Apartsin, E.K.; Grigoryeva, A.E.; Malrin-Fournol, A.; Ryabchikova, E.I.; Venyaminova, A.G.; Mignani, S.; Caminade, A.-M.; Majoral, J.-P. Hydrogels of Polycationic Acetohydrazone-Modified Phosphorus Dendrimers for Biomedical Applications: Gelation Studies and Nucleic Acid Loading. Pharmaceutics 2018, 10, 120.

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