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Viruses 2011, 3(4), 278-292;

Actin’ up: Herpesvirus Interactions with Rho GTPase Signaling

Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Sint-Pietersnieuwstraat 25, B-9000 Ghent, Belgium
Author to whom correspondence should be addressed.
Received: 31 January 2011 / Revised: 15 March 2011 / Accepted: 16 March 2011 / Published: 24 March 2011
(This article belongs to the Special Issue Cytoskeleton in Viral Infections)
PDF [321 KB, uploaded 12 May 2015]


Herpesviruses constitute a very large and diverse family of DNA viruses, which can generally be subdivided in alpha-, beta- and gammaherpesvirus subfamilies. Increasing evidence indicates that many herpesviruses interact with cytoskeleton-regulating Rho GTPase signaling pathways during different phases of their replication cycle. Because of the large differences between herpesvirus subfamilies, the molecular mechanisms and specific consequences of individual herpesvirus interactions with Rho GTPase signaling may differ. However, some evolutionary distinct but similar general effects on Rho GTPase signaling and the cytoskeleton have also been reported. Examples of these include Rho GTPase-mediated nuclear translocation of virus during entry in a host cell and Rho GTPase-mediated viral cell-to-cell spread during later stages of infection. The current review gives an overview of both general and individual interactions of herpesviruses with Rho GTPase signaling.
Keywords: herpesvirus; Rho GTPases; actin; cytoskeleton herpesvirus; Rho GTPases; actin; cytoskeleton
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Van den Broeke, C.; Favoreel, H.W. Actin’ up: Herpesvirus Interactions with Rho GTPase Signaling. Viruses 2011, 3, 278-292.

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