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Article

The Antiviral Effect of the Chemical Compounds Targeting DED/EDh Motifs of the Viral Proteins on Lymphocytic Choriomeningitis Virus and SARS-CoV-2

1
Department of Virology, Institute of Tropical Medicine and Leading Program, Graduate School of Biomedical Science, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
2
Department of Chemistry, Biotechnology and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan
3
National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
*
Authors to whom correspondence should be addressed.
Academic Editors: Michael B.A. Oldstone and Juan C. De la Torre
Viruses 2021, 13(7), 1220; https://doi.org/10.3390/v13071220
Received: 18 May 2021 / Revised: 14 June 2021 / Accepted: 23 June 2021 / Published: 24 June 2021
(This article belongs to the Special Issue In Memory of Stefan Kunz)
Arenaviruses and coronaviruses include several human pathogenic viruses, such as Lassa virus, Lymphocytic choriomeningitis virus (LCMV), SARS-CoV, MERS-CoV, and SARS-CoV-2. Although these viruses belong to different virus families, they possess a common motif, the DED/EDh motif, known as an exonuclease (ExoN) motif. In this study, proof-of-concept studies, in which the DED/EDh motif in these viral proteins, NP for arenaviruses, and nsp14 for coronaviruses, could be a drug target, were performed. Docking simulation studies between two structurally different chemical compounds, ATA and PV6R, and the DED/EDh motifs in these viral proteins indicated that these compounds target DED/EDh motifs. The concentration which exhibited modest cell toxicity was used with these compounds to treat LCMV and SARS-CoV-2 infections in two different cell lines, A549 and Vero 76 cells. Both ATA and PV6R inhibited the post-entry step of LCMV and SARS-CoV-2 infection. These studies strongly suggest that DED/EDh motifs in these viral proteins could be a drug target to combat two distinct viral families, arenaviruses and coronaviruses. View Full-Text
Keywords: Lymphocytic choriomeningitis virus (LCMV); SARS-CoV-2; antivirals; exonuclease (ExoN) motif; DED/EDh motif Lymphocytic choriomeningitis virus (LCMV); SARS-CoV-2; antivirals; exonuclease (ExoN) motif; DED/EDh motif
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MDPI and ACS Style

Ngwe Tun, M.M.; Morita, K.; Ishikawa, T.; Urata, S. The Antiviral Effect of the Chemical Compounds Targeting DED/EDh Motifs of the Viral Proteins on Lymphocytic Choriomeningitis Virus and SARS-CoV-2. Viruses 2021, 13, 1220. https://doi.org/10.3390/v13071220

AMA Style

Ngwe Tun MM, Morita K, Ishikawa T, Urata S. The Antiviral Effect of the Chemical Compounds Targeting DED/EDh Motifs of the Viral Proteins on Lymphocytic Choriomeningitis Virus and SARS-CoV-2. Viruses. 2021; 13(7):1220. https://doi.org/10.3390/v13071220

Chicago/Turabian Style

Ngwe Tun, Mya M., Kouichi Morita, Takeshi Ishikawa, and Shuzo Urata. 2021. "The Antiviral Effect of the Chemical Compounds Targeting DED/EDh Motifs of the Viral Proteins on Lymphocytic Choriomeningitis Virus and SARS-CoV-2" Viruses 13, no. 7: 1220. https://doi.org/10.3390/v13071220

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