Next Article in Journal
The Cross-Talk between Thrombosis and Inflammatory Storm in Acute and Long-COVID-19: Therapeutic Targets and Clinical Cases
Previous Article in Journal
Special Issue: “Viral Replication Complexes”
 
 
Communication

Pathogenicity of H5N8 High Pathogenicity Avian Influenza Virus in Chickens and Ducks from South Korea in 2020–2021

Avian Influenza Research & Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, Gyeongsangbuk-do, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Feng Li
Viruses 2021, 13(10), 1903; https://doi.org/10.3390/v13101903
Received: 25 August 2021 / Revised: 17 September 2021 / Accepted: 19 September 2021 / Published: 23 September 2021
(This article belongs to the Section Animal Viruses)
During the 2020–2021 winter season, an outbreak of clade 2.3.4.4b H5N8 high pathogenicity avian influenza (HPAI) virus occurred in South Korea. Here, we evaluated the pathogenicity and transmissibility of A/mandarin duck/Korea/H242/2020 (H5N8) (H242/20(H5N8)) first isolated from this outbreak in specific pathogen-free (SPF) chickens and commercial ducks in comparison with those of A/duck/Korea/HD1/2017(H5N6) (HD1/17(H5N6)) from a previous HPAI outbreak in 2017–2018. In chickens, the 50% chicken lethal dose and mean death time of H242/20(H5N8) group were 104.5 EID50 and 4.3 days, respectively, which indicate less virulent than those of HD1/17(H5N6) (103.6 EID50 and 2.2 days). Whereas, chickens inoculated with H242/20(H5N8) survived longer and had a higher titer of viral shedding than those inoculated with HD1/17(H5N6), which may increase the risk of viral contamination on farms. All ducks infected with either HPAI virus survived without clinical symptoms. In addition, they exhibited a longer virus shedding period and a higher transmission rate, indicating that ducks may play an important role as a silent carrier of both HPAI viruses. These results suggest that the pathogenic characteristics of HPAI viruses in chickens and ducks need to be considered to effectively control HPAI outbreaks in the field. View Full-Text
Keywords: high pathogenicity avian influenza; pathogenicity; chicken; ducks high pathogenicity avian influenza; pathogenicity; chicken; ducks
Show Figures

Figure 1

MDPI and ACS Style

Park, M.-J.; Cha, R.M.; Kye, S.-J.; Lee, Y.-N.; Kim, N.-Y.; Baek, Y.-G.; Heo, G.-B.; Sagong, M.; Lee, K.-N.; Lee, Y.-J.; Lee, E.-K. Pathogenicity of H5N8 High Pathogenicity Avian Influenza Virus in Chickens and Ducks from South Korea in 2020–2021. Viruses 2021, 13, 1903. https://doi.org/10.3390/v13101903

AMA Style

Park M-J, Cha RM, Kye S-J, Lee Y-N, Kim N-Y, Baek Y-G, Heo G-B, Sagong M, Lee K-N, Lee Y-J, Lee E-K. Pathogenicity of H5N8 High Pathogenicity Avian Influenza Virus in Chickens and Ducks from South Korea in 2020–2021. Viruses. 2021; 13(10):1903. https://doi.org/10.3390/v13101903

Chicago/Turabian Style

Park, Min-Ji, Ra Mi Cha, Soo-Jeong Kye, Yu-Na Lee, Na-Yeong Kim, Yoon-Gi Baek, Gyeong-Beom Heo, Mingeun Sagong, Kwang-Nyeong Lee, Youn-Jeong Lee, and Eun-Kyoung Lee. 2021. "Pathogenicity of H5N8 High Pathogenicity Avian Influenza Virus in Chickens and Ducks from South Korea in 2020–2021" Viruses 13, no. 10: 1903. https://doi.org/10.3390/v13101903

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop