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Viruses 2019, 11(3), 279;

A Novel Orthohepadnavirus Identified in a Dead Maxwell’s Duiker (Philantomba maxwellii) in Taï National Park, Côte d’Ivoire

Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, 13353 Berlin, Germany
Viral Evolution, Robert Koch Institute, 13353 Berlin, Germany
Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10027, USA
Institute of Microbiology and Epizootics, Freie Universität Berlin, 14163 Berlin, Germany
World Wide Fund for Nature, Dzanga-Sangha Protected Areas, Bangui BP 1053, Central African Republic
Laboratoire National D’appui au Développement Agricole/Laboratoire Central de Pathologie Animale, Bingerville BP206, Côte d’Ivoire
Authors to whom correspondence should be addressed.
These authors contributed equally to the manuscript.
Received: 28 February 2019 / Revised: 11 March 2019 / Accepted: 16 March 2019 / Published: 19 March 2019
(This article belongs to the Section Animal Viruses)
PDF [934 KB, uploaded 19 March 2019]


New technologies enable viral discovery in a diversity of hosts, providing insights into viral evolution. We used one such approach, the virome capture sequencing for vertebrate viruses (VirCapSeq-VERT) platform, on 21 samples originating from six dead Maxwell’s duikers (Philantomba maxwellii) from Taï National Park, Côte d’Ivoire. We detected the presence of an orthohepadnavirus in one animal and characterized its 3128 bp genome. The highest viral copy numbers were detected in the spleen, followed by the lung, blood, and liver, with the lowest copy numbers in the kidney and heart; the virus was not detected in the jejunum. Viral copy numbers in the blood were in the range known from humans with active chronic infections leading to liver histolytic damage, suggesting this virus could be pathogenic in duikers, though many orthohepadnaviruses appear to be apathogenic in other hosts, precluding a formal test of this hypothesis. The virus was not detected in 29 other dead duiker samples from the Côte d’Ivoire and Central African Republic, suggesting either a spillover event or a low prevalence in these populations. Phylogenetic analysis placed the virus as a divergent member of the mammalian clade of orthohepadnaviruses, though its relationship to other orthohepadnaviruses remains uncertain. This represents the first orthohepadnavirus described in an artiodactyl. We have tentatively named this new member of the genus Orthohepadnavirus (family Hepadnaviridae), Taï Forest hepadnavirus. Further studies are needed to determine whether it, or some close relatives, are present in a broader range of artiodactyls, including livestock. View Full-Text
Keywords: virus; hepadnavirus; Orthohepadnavirus; discovery; hybridization capture; bovid; artiodactyls; sequencing virus; hepadnavirus; Orthohepadnavirus; discovery; hybridization capture; bovid; artiodactyls; sequencing

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Gogarten, J.F.; Ulrich, M.; Bhuva, N.; Garcia, J.; Jain, K.; Lee, B.; Löhrich, T.; Oleynik, A.; Couacy-Hymann, E.; Fuh Neba, T.; Mishra, N.; Briese, T.; Calvignac-Spencer, S.; Lipkin, W.I.; Leendertz, F.H. A Novel Orthohepadnavirus Identified in a Dead Maxwell’s Duiker (Philantomba maxwellii) in Taï National Park, Côte d’Ivoire. Viruses 2019, 11, 279.

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