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Open AccessArticle

A Novel Exploration of a Combination of Gambogic Acid with TiO2 Nanofibers: The Photodynamic Effect for HepG2 Cell Proliferation

1
Laboratory Animal Center, Nantong University, Nantong 226001, China
2
State Key Lab of Bioelectronics (Chien-Shiung WU Laboratory), Southeast University, Nanjing 210096, China
3
State Key Lab of Materials-Oriented Chemical Engineering, Nanjing University of Technology, Nanjing 210009, China
4
Department of Hematology, the affiliated Zhongda Hospital, Southeast University, Nanjing 210009, China
*
Author to whom correspondence should be addressed.
Materials 2014, 7(9), 6865-6878; https://doi.org/10.3390/ma7096865
Received: 17 July 2014 / Revised: 28 August 2014 / Accepted: 28 August 2014 / Published: 24 September 2014
(This article belongs to the Special Issue Materials for Drug Delivery)
As a good photosensitizer, TiO2 nanomaterials show potential biomedical applications, such as drug carriers or enhancers in photodynamic therapy. In this contribution, novel nanocomposites through the blending of TiO2 nanofibers with the active compound, gambogic acid (GA), were explored, and the results showed that GA could inhibit cancer cell proliferation in a time-dependent and dose-dependent manner, inducing apoptosis and cell cycle arrest at the G0/G1 phase in HepG2 cells. It is evident that after the GA-TiO2 nanocomposites were cultured with the cancer cells, the cooperation effect could effectively enhance the cytotoxicity of GA for HepG2 cells. Meanwhile, if activated by UV irradiation, under the presence of GA-TiO2 nanocomposites, this would lead to significant apoptosis and necrosis for HepG2 cells with a photodynamic therapy (PDT) effect. Associated with the controlled drug-release from these nanocomposites, TiO2 nanofibers could readily cut down the drug consumption in HepG2 cells and reduce the side-effect for the normal cells and tissue, which may be further utilized in the therapeutic alliance for cancer therapy. View Full-Text
Keywords: TiO2 nanofibers; gambogic acid; cancer cell; PDT; associated therapy TiO2 nanofibers; gambogic acid; cancer cell; PDT; associated therapy
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Li, J.; Wang, X.; Shao, Y.; Lu, X.; Chen, B. A Novel Exploration of a Combination of Gambogic Acid with TiO2 Nanofibers: The Photodynamic Effect for HepG2 Cell Proliferation. Materials 2014, 7, 6865-6878.

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