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Article

A Novel, Nontoxic and Scalable Process to Produce Lipidic Vehicles

Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece
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Materials 2020, 13(21), 5035; https://doi.org/10.3390/ma13215035
Received: 12 October 2020 / Revised: 28 October 2020 / Accepted: 5 November 2020 / Published: 8 November 2020
(This article belongs to the Special Issue Drug Delivery: Recent Developments and Future Prospects)
Lipidic vehicles are novel industrial products, utilized as components for pharmaceutical, cosmeceutical and nutraceutical formulations. The present study concerns a newly invented method to produce lipidic vehicles in the nanoscale that is simple, nontoxic, versatile, time-efficient, low-cost and easy to scale up. The process is a modification of the heating method (MHM) and comprises (i) providing a mixture of an amphiphilic lipid and a charged lipid and/or a fluidity regulator in a liquid medium composed of water and a liquid polyol, (ii) stirring and heating the mixture in two heating steps, wherein the temperature of the second step is higher than the temperature of the first step and (iii) allowing the mixture to cool down to room temperature. The process leads to the self-assembly of nanoparticles of small size and good homogeneity, compared with conventional approaches that require additional size reduction steps. In addition, the incorporation of bioactive molecules, such as drugs, inside the nanoparticles is possible, while lyophilization of the products provides long-term stability. Most importantly, the absence of toxic solvents and the simplicity guarantee the safety and scalability of the process, distinguishing it from most prior art processes to produce lipidic vehicles. View Full-Text
Keywords: modified heating method (MHM); lipidic vehicles; amphiphilic lipids; liquid polyol; physicochemical properties; lyophilization modified heating method (MHM); lipidic vehicles; amphiphilic lipids; liquid polyol; physicochemical properties; lyophilization
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MDPI and ACS Style

Naziris, N.; Pippa, N.; Demetzos, C. A Novel, Nontoxic and Scalable Process to Produce Lipidic Vehicles. Materials 2020, 13, 5035. https://doi.org/10.3390/ma13215035

AMA Style

Naziris N, Pippa N, Demetzos C. A Novel, Nontoxic and Scalable Process to Produce Lipidic Vehicles. Materials. 2020; 13(21):5035. https://doi.org/10.3390/ma13215035

Chicago/Turabian Style

Naziris, Nikolaos, Natassa Pippa, and Costas Demetzos. 2020. "A Novel, Nontoxic and Scalable Process to Produce Lipidic Vehicles" Materials 13, no. 21: 5035. https://doi.org/10.3390/ma13215035

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