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Open AccessArticle

Fabrication and Cytotoxicity of Fucoidan-Cisplatin Nanoparticles for Macrophage and Tumor Cells

Department of Bioscience and Biotechnology, National Taiwan Ocean University, No. 2, Beining Road, Keelung City 202, Taiwan
Seafood Technology Division, Council of Agriculture Fisheries Research Institute, No. 199 Hou-Ih Road, Keelung City 202, Taiwan
Authors to whom correspondence should be addressed.
Academic Editor: Maryam Tabrizian
Materials 2017, 10(3), 291;
Received: 26 December 2016 / Revised: 3 March 2017 / Accepted: 6 March 2017 / Published: 14 March 2017
(This article belongs to the Section Biomaterials)
Fucoidan, an anionic, sulfated polysaccharide from brown seaweed, is known to exhibit antitumor and immunomodulatory functions. To develop an immune protection and chemotherapeutic agent, fucoidan-cisplatin nanoparticles (FCNPs) were designed. FCNPs were prepared by mixing cisplatin with fucoidan solution or fucoidan with cisplatin solution, followed by dialysis to remove trace elements. The nanoparticles, comprising 10 mg of fucoidan and 2 mg of cisplatin, which exhibited the highest cisplatin content and loading efficiency during the production process, were named as Fu100Cis20. The cisplatin content, cisplatin loading efficiency, nanoparticle size, and zeta potential of Fu100Cis20 were 18.9% ± 2.7%, 93.3% ± 7.8%, 181.2 ± 21.0 nm, and −67.4 ± 2.3 mV, respectively. Immune protection assay revealed that Fu100Cis20-treated RAW264.7 cells were protected from the cytotoxicity of cisplatin. Furthermore, antitumor assay indicated that Fu100Cis20-treated HCT-8 cells showed stronger cytotoxicity than those treated with cisplatin alone. These results suggested that fucoidan-based nanoparticles exhibited suitable particle size and high drug encapsulation, and that Fu100Cis20 has potential application in both immunotherapy and chemotherapy. View Full-Text
Keywords: fucoidan; cisplatin; immune protection; anti-tumor activity fucoidan; cisplatin; immune protection; anti-tumor activity
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Hwang, P.-A.; Lin, X.-Z.; Kuo, K.-L.; Hsu, F.-Y. Fabrication and Cytotoxicity of Fucoidan-Cisplatin Nanoparticles for Macrophage and Tumor Cells. Materials 2017, 10, 291.

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