Journal of the American Podiatric Medical Association

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Open AccessArticle

Podiatric Physicians and Genomic Medicine. The Coming Medical Revolution: Are We (Getting) Ready?

by Leonard A. Levy

J. Am. Podiatr. Med. Assoc. 2017, 107(4), 347-354; https://doi.org/10.7547/15-217 - 1 Jul 2017

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It has been more than 14 years since identification of the human genome. This phenomenon is creating a revolution in all components of the health-care world. To date, little has been included in the podiatric medical literature despite the fact that so many [...] Read more.

It has been more than 14 years since identification of the human genome. This phenomenon is creating a revolution in all components of the health-care world. To date, little has been included in the podiatric medical literature despite the fact that so many of the conditions affecting the pedal extremity have genomic implications. Genomics will have a major effect on prevention, diagnosis, and patient management and needs to be included in podiatric medical practice as well as in the curriculum of podiatric medical schools. (J Am Podiatr Med Assoc 107(4): 347-354, 2017) Full article

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Open AccessArticle

Osteoid Osteoma at the Proximal Diaphysis of the Fifth Metatarsal. A Case Report

by Muhammet Baybars Ataoglu, Ali Kh. Ali, Mustafa Ozer, Hüseyin Nevzat Topcu, Mehmet Cetinkaya and Gamze Kulduk

J. Am. Podiatr. Med. Assoc. 2017, 107(4), 342-346; https://doi.org/10.7547/15-059 - 1 Jul 2017

Cited by 5 | Viewed by 53

Abstract

The foot is rarely the focus of osteoid osteoma, and only a few of those cases are related to the fifth metatarsal. The present case demonstrates that atypical symptoms with suspicious findings on plain radiographs that are not associated with trauma must be [...] Read more.

The foot is rarely the focus of osteoid osteoma, and only a few of those cases are related to the fifth metatarsal. The present case demonstrates that atypical symptoms with suspicious findings on plain radiographs that are not associated with trauma must be analyzed carefully to determine the nature of the lesion and perform the precise treatment to obtain and sustain the cure. A 29-year-old man presented to the outpatient clinic with a 2-year history of chronic pain in the lateral aspect of his left forefoot. The onset was not related to trauma, surgery, local infection, osteomyelitis, or another entity regarding the proximal fifth metatarsal. The patient noted that the pain was aggravated at night and typically subsided with the use of salicylates or other nonsteroidal antiinflammatory drugs. Initial plain radiographs demonstrated cortical thickening and a lytic lesion at the proximal diaphysis of the fifth metatarsal. Because the pain relief was transient, we suspected an osteoid osteoma lesion, and subsequent magnetic resonance imaging manifested pathognomonic signs of subperiosteal osteoid osteoma. Diagnosis was followed by planning of the surgery that ended the patient’s symptoms. (J Am Podiatr Med Assoc 107(4): 342-346, 2017) Full article

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Open AccessArticle

A Novel Technique to Determine Foot Contribution to Limb-Length Discrepancy

by George Lane

J. Am. Podiatr. Med. Assoc. 2017, 107(4), 340-341; https://doi.org/10.7547/16-062 - 1 Jul 2017

Cited by 1 | Viewed by 47

Abstract

Evaluation for limb-length discrepancy is an important part of the biomechanical work-up in the podiatric musculoskeletal exam. By understanding the foot’s contribution to such a discrepancy, the podiatric clinician will have better insight regarding treatment strategy. This technique will provide the clinician with [...] Read more.

Evaluation for limb-length discrepancy is an important part of the biomechanical work-up in the podiatric musculoskeletal exam. By understanding the foot’s contribution to such a discrepancy, the podiatric clinician will have better insight regarding treatment strategy. This technique will provide the clinician with a simple method to gain such insight. (J Am Podiatr Med Assoc 107(4): 340-341, 2017) Full article

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Open AccessArticle

Synovial Lipoma of the Subtalar Joint. A Rare Case Report

by Jeffrey M. Whitaker, Sarah Richards, Michael J. LeCastre and Thomas G. Hooke

J. Am. Podiatr. Med. Assoc. 2017, 107(4), 337-339; https://doi.org/10.7547/15-140 - 1 Jul 2017

Cited by 1 | Viewed by 55

Abstract

Lipomas are benign adipose masses that are rarely associated with synovial membranes. In addition, there are only a few reports describing synovial lipomas in the foot. No reported occurrence of this lesion in the subtalar joint currently exists. This case report documents the [...] Read more.

Lipomas are benign adipose masses that are rarely associated with synovial membranes. In addition, there are only a few reports describing synovial lipomas in the foot. No reported occurrence of this lesion in the subtalar joint currently exists. This case report documents the presentation, clinical evaluation, advanced imaging, and surgical management of a 45-year-old man with a large synovial lipoma of the subtalar joint. (J Am Podiatr Med Assoc 107(4): 337-339, 2017) Full article

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Open AccessArticle

Rare Giant Cell Tumor of the Distal Flexor Digitorum Longus Tendon Sheath and Early Diagnosis with Use of Magnetic Resonance Imaging

by Michael Levi and Jordan Crafton

J. Am. Podiatr. Med. Assoc. 2017, 107(4), 333-336; https://doi.org/10.7547/16-163 - 1 Jul 2017

Cited by 7 | Viewed by 58

Abstract

Giant-cell tumor of the tendon sheath (GCT-TS) is an uncommon occurrence for a foot and ankle surgeon. However, there is a need to recognize the symptoms of typical and atypical presentations of this pathology. These benign neoplasms are recognized clinically as a soft-tissue [...] Read more.

Giant-cell tumor of the tendon sheath (GCT-TS) is an uncommon occurrence for a foot and ankle surgeon. However, there is a need to recognize the symptoms of typical and atypical presentations of this pathology. These benign neoplasms are recognized clinically as a soft-tissue mass that is usually painless and palpable. The foot and ankle account for only 3% to 5% of all GCT-TS in the body, with most being located in the hand. Giant cell tumor in the tendon sheath occurring in the foot and ankle is usually encountered on the lateral ankle and dorsum of the foot, occupying the extensor tendons. Additionally, it is commonly misdiagnosed clinically. This case study illustrates how early use of magnetic resonance imaging decreased patient morbidity with early recognition and excision of GCT-TS. (J Am Podiatr Med Assoc 107(4): 333-336, 2017) Full article

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Open AccessArticle

Giant Plantar Epidermoid Cyst with Invasion of the Interosseous Muscles

by Antonio Córdoba-Fernandez, Adrián Lobo-Martín, Carlos Escudero-Severín and Victoria Eugenia Córdoba-Jiménez

J. Am. Podiatr. Med. Assoc. 2017, 107(4), 329-332; https://doi.org/10.7547/16-054 - 1 Jul 2017

Cited by 2 | Viewed by 68

Abstract

Epidermoid cysts of the sole of the foot are rare lesions that must be differentiated from other, more common subcutaneous pathologic abnormalities located on the sole. Cases of epidermoid cysts that extend to the interosseous musculature are rarer still. We report the case [...] Read more.

Epidermoid cysts of the sole of the foot are rare lesions that must be differentiated from other, more common subcutaneous pathologic abnormalities located on the sole. Cases of epidermoid cysts that extend to the interosseous musculature are rarer still. We report the case of a giant epidermal cyst in a 64-year-old individual that extended to the intrinsic musculature of the third space of the right foot and that was diagnosed after fine-needle aspiration biopsy and subsequent cytologic study. Differential diagnosis of these lesions should be made with the support of additional imaging tests, and diagnostic confirmation should always be obtained after surgical removal and subsequent histopathologic study. (J Am Podiatr Med Assoc 107(4): 329-332, 2017) Full article

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Open AccessArticle

Pedal Cutaneous Manifestations of Tuberous Sclerosis

by Rachel E. Johnson and Kimberly Avramaut

J. Am. Podiatr. Med. Assoc. 2017, 107(4), 324-328; https://doi.org/10.7547/15-225 - 1 Jul 2017

Cited by 1 | Viewed by 50

Abstract

This case report concerns a patient with a painful soft-tissue mass on his fourth toe. He was evaluated for this soft-tissue mass and was diagnosed as having tuberous sclerosis. The podiatric physician should be able to evaluate a patient with a lower-extremity complaint [...] Read more.

This case report concerns a patient with a painful soft-tissue mass on his fourth toe. He was evaluated for this soft-tissue mass and was diagnosed as having tuberous sclerosis. The podiatric physician should be able to evaluate a patient with a lower-extremity complaint and relate whether this complaint may correlate with a systemic disorder. This case report will make the podiatric physician more aware of tuberous sclerosis and the manifestations of the disorder. (J Am Podiatr Med Assoc 107(4): 324-328, 2017) Full article

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Open AccessArticle

Fibular-Lengthening Osteotomy to Correct a Malunited Ankle Fracture Using Fresh-Frozen Femoral Head Allograft. A Case Study

by Harry J. Visser, Khawar Malik and Robert A. Djali

J. Am. Podiatr. Med. Assoc. 2017, 107(4), 318-323; https://doi.org/10.7547/15-207 - 1 Jul 2017

Cited by 3 | Viewed by 45

Abstract

Malreduction of a distal fibular fracture can lead to degenerative changes in the ankle joint. Previous studies have shown that the selective use of various fibular reconstructive osteotomies may halt the progression of degenerative arthritis by restoring the normal tibiotalar contact area and [...] Read more.

Malreduction of a distal fibular fracture can lead to degenerative changes in the ankle joint. Previous studies have shown that the selective use of various fibular reconstructive osteotomies may halt the progression of degenerative arthritis by restoring the normal tibiotalar contact area and decreasing the stresses on the articular cartilage. In this case report, we achieved alignment with restoration of the talocrural angle and Shenton’s line of the ankle using a transfibular osteotomy and an allogeneic fresh-frozen femoral head graft to fill the resultant defect. The advantage of this procedure is twofold. First, fibularlengthening procedures may potentially decrease the eventual need for joint-sacrificing procedures such as an arthrodesis or arthroplasty. Second, an allograft allows for larger deficit correction without concern for donor-site morbidity. To our knowledge, this is the first case report using a fresh-frozen femoral head allograft for a fibular-lengthening osteotomy in the podiatric medical literature. Further research with larger patient populations is needed to establish whether fresh-frozen femoral head allograft is a reliable graft option for fibular-lengthening procedures. (J Am Podiatr Med Assoc 107(4): 318-323, 2017) Full article

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Open AccessReview

Remote Ischemic Conditioning. Promising Potential in Wound Repair in Diabetes?

by Jano A. Boghossian, Bellal Joseph, Marvin J. Slepian and David G. Armstrong

J. Am. Podiatr. Med. Assoc. 2017, 107(4), 313-317; https://doi.org/10.7547/15-172 - 1 Jul 2017

Cited by 6 | Viewed by 55

Abstract

Remote ischemic conditioning involves the use of a blood pressure cuff or similar device to induce brief (3–5 min) episodes of limb ischemia. This, in turn, seems to activate a group of distress signals that has shown the potential ability to improve healing [...] Read more.

Remote ischemic conditioning involves the use of a blood pressure cuff or similar device to induce brief (3–5 min) episodes of limb ischemia. This, in turn, seems to activate a group of distress signals that has shown the potential ability to improve healing of the heart muscle and other organ systems. Until recently, this has not been tested in people with diabetic foot ulcers. The purpose of this review was to provide background on remote ischemic conditioning and recent data to potentially support its use as an adjunct to healing diabetic foot ulcers and other types of tissue loss. We believe that this inexpensive therapy has the potential to be deployed and incorporated into a variety of other therapies to prime patients for healing and to reduce morbidity in patients with this common, complex, and costly complication. (J Am Podiatr Med Assoc 107(4): 313-317, 2017) Full article

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Open AccessArticle

Foot Pain in Relation to Ipsilateral and Contralateral Lower-Extremity Pain in a Population-Based Study

by Alyssa B. Dufour, Brian Halpern, Rock G. Positano, Howard J. Hillstrom and Marian T. Hannan

J. Am. Podiatr. Med. Assoc. 2017, 107(4), 307-312; https://doi.org/10.7547/15-182 - 1 Jul 2017

Cited by 3 | Viewed by 61

Abstract

Background: Clinical observations note that foot pain can be linked to contralateral pain at the knee or hip, yet we are unaware of any community-based studies that have investigated the sidedness of pain. Because clinic-based patient samples are often different from the general [...] Read more.

Background: Clinical observations note that foot pain can be linked to contralateral pain at the knee or hip, yet we are unaware of any community-based studies that have investigated the sidedness of pain. Because clinic-based patient samples are often different from the general population, the purpose of this study was to determine whether knee or hip pain is more prevalent with contralateral foot pain than with ipsilateral foot pain in a population-based cohort. Methods: Framingham Foot Study participants (2002–2008) with information on foot, knee, and hip pain were included in this cross-sectional analysis. Foot pain was queried as pain, aching, or stiffness on most days. Using a manikin diagram, participants indicated whether they had experienced pain, aching, or stiffness at the hip or knee and specified the side of any reported pain. Sex-specific multinomial logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals for the association of foot pain with knee and hip pain, adjusting for age and body mass index. Results: In the 2,181 participants, the mean 6 SD age was 64 6 9 years; 56% were women, and the mean body mass index was 28.6. For men and women, bilateral foot pain was associated with increased odds of knee pain on any side (ORs =2–3; P < .02). Men with foot pain were more likely to have ipsilateral hip pain (ORs = 2–4; P<.03), whereas women with bilateral foot pain were more likely to have hip pain on any side (OR = 2–3; P < .02). Conclusions: Bilateral foot pain was associated with increased odds of knee and hip pain in men and women. For ipsilateral foot and hip pain, men had a stronger effect compared with women. (J Am Podiatr Med Assoc 107(4): 307-312, 2017) Full article

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Open AccessArticle

Pregnancy and Pelvic Girdle Pain. Analysis of Center of Pressure During Gait

by Floriane Kerbourc'H, Jeanne Bertuit, Véronique Feipel and Marcel Rooze

J. Am. Podiatr. Med. Assoc. 2017, 107(4), 299-306; https://doi.org/10.7547/15-087 - 1 Jul 2017

Cited by 6 | Viewed by 47

Abstract

Background: A woman’s body undergoes many changes during pregnancy, and it adapts by developing compensatory strategies, which can be sources of pain. We sought to analyze the effects of pregnancy and pelvic girdle pain (PGP) on center of pressure (COP) parameters during gait [...] Read more.

Background: A woman’s body undergoes many changes during pregnancy, and it adapts by developing compensatory strategies, which can be sources of pain. We sought to analyze the effects of pregnancy and pelvic girdle pain (PGP) on center of pressure (COP) parameters during gait at different speeds. Methods: Sixty-one healthy pregnant women, 66 women with PGP between 18 and 27 weeks of pregnancy, and 22 healthy nonpregnant women walked at different velocities (slow, preferential, and fast) on a walkway with built-in pressure sensors. An analysis of variance was performed to determine the effects of gait speed and group on COP parameters. Results: In healthy pregnant women and women with PGP, COP parameters were significantly modified compared with those in nonpregnant women (P < .01). Support time was increased regardless of gait speed, and anteroposterior COP displacement was significantly decreased for women with PGP compared with healthy pregnant women. In addition, mediolateral COP displacement was significantly decreased in pregnant women compared with nongravid women. Conclusions: Gait speed influenced COP displacement and velocity parameters, and gait velocity potentiated the effect of pregnancy on the different parameters. Pelvic girdle pain had an influence on COP anteroposterior length only. With COP parameters being only slightly modified by PGP, the gait of pregnant women with PGP was similar to that of healthy pregnant women but differed from that of nonpregnant women. (J Am Podiatr Med Assoc 107(4): 299-306, 2017) Full article

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Open AccessArticle

Lower-Leg and Foot Contributions to Turnout in University- Level Female Ballet Dancers. A Preliminary Investigation

by Sarah L. Carter, Alan R. Bryant and Luke S. Hopper

J. Am. Podiatr. Med. Assoc. 2017, 107(4), 292-298; https://doi.org/10.7547/15-142 - 1 Jul 2017

Cited by 5 | Viewed by 54

Abstract

Background: Turnout in ballet is produced through summation of the joint structure characteristics and ranges of motion at the hip, knee, ankle, and foot. Contributions of the hip joint to functional turnout in dancers have received extensive examination, whereas little is known about [...] Read more.

Background: Turnout in ballet is produced through summation of the joint structure characteristics and ranges of motion at the hip, knee, ankle, and foot. Contributions of the hip joint to functional turnout in dancers have received extensive examination, whereas little is known about contributions from the knee, ankle, and foot. The aim of this study was to explore the nonhip components of turnout to dancers’ functional turnout in first position by assessing passive external tibiofemoral rotation and active measures of foot pronation, ie, navicular drop and Foot Posture Index. Methods: Nineteen female university-level dance students aged 16 to 19 years participated in this descriptive correlational study. External tibiofemoral rotation, navicular drop, Foot Posture Index, and functional turnout were measured for the participants’ right and left legs. Results: Regression analyses revealed a weak relationship between passive external tibiofemoral rotation and functional turnout. Correlation analysis revealed a moderate negative relationship between passive tibiofemoral external rotation and the Foot Posture Index in functional turnout. Conclusions: These findings suggest that the lower leg does contribute to dancers’ overall position of functional turnout. However, current methods are not useful in predicting a dancer’s lower-leg contribution and alignment in functional turnout in first position. (J Am Podiatr Med Assoc 107(4): 292-298, 2017) Full article

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Open AccessArticle

Evaluating Quality of Life in Patients with Hallux Abducto Valgus Deformity After a Taping Technique

by Malcolm Paul Formosa, Alfred Gatt and Cynthia Formosa

J. Am. Podiatr. Med. Assoc. 2017, 107(4), 287-291; https://doi.org/10.7547/15-110 - 1 Jul 2017

Cited by 5 | Viewed by 58

Abstract

Background: The aim of this study was to determine the quality of life in patients living with hallux abducto valgus deformity before and after a taping technique. Methods: This study used a time series, quasi-experimental, same-subject design. Thirty-five patients with hallux abducto valgus [...] Read more.

Background: The aim of this study was to determine the quality of life in patients living with hallux abducto valgus deformity before and after a taping technique. Methods: This study used a time series, quasi-experimental, same-subject design. Thirty-five patients with hallux abducto valgus were recruited in this study. Nonelastic zinc oxide tape was applied for 4 weeks. The Foot Health Status Questionnaire was used to assess the quality of life of participants before and after the intervention. The paired samples t test was used to test for statistical significance at the 95% confidence level. Results: In this study, a statistical reduction was seen in foot pain, foot function, and general foot health (P < .0001) after applying the nonelastic zinc oxide tape for 10 hours daily for 4 weeks. No statistically significant difference was found in the remaining domains of the Foot Health Status Questionnaire, although a difference in mean scores was observed. Conclusions: Treatment with nonelastic zinc oxide tape led to improved management of hallux abducto valgus and better quality of life; it is a safe, easy-to-use method with minimal adverse effects. Future studies should evaluate this method using larger sample groups and longer treatment periods while comparing this method with alternative treatment approaches, such as exercise or orthotic devices. (J Am Podiatr Med Assoc 107(4): 287-291, 2017) Full article

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Open AccessArticle

Onychomycosis Infections. Do Polymerase Chain Reaction and Culture Reports Agree?

by Aditya K. Gupta and Kerry-Ann Nakrieko

J. Am. Podiatr. Med. Assoc. 2017, 107(4), 280-286; https://doi.org/10.7547/15-136 - 1 Jul 2017

Cited by 28 | Viewed by 49

Abstract

Background: Mycological culture is the traditional method for identifying infecting agents of onychomycosis despite high false-negative results, slower processing, and complications surrounding nondermatophyte mold (NDM) infections. Molecular polymerase chain reaction (PCR) methods are faster and suited for ascertaining NDM infections. Methods: To measure [...] Read more.

Background: Mycological culture is the traditional method for identifying infecting agents of onychomycosis despite high false-negative results, slower processing, and complications surrounding nondermatophyte mold (NDM) infections. Molecular polymerase chain reaction (PCR) methods are faster and suited for ascertaining NDM infections. Methods: To measure agreement between culture and PCR methods for identification of infecting species of suspected onychomycosis, single toenail samples from 167 patients and repeated serial samples from 43 patients with suspected onychomycosis were processed by culture and PCR for identification of 16 dermatophytes and five NDMs. Agreement between methods was quantified using the kappa statistic (j). Results: The methods exhibited fair agreement for the identification of all infecting organisms (single samples: j = 0.32; repeated samples: j = 0.38). For dermatophytes, agreement was moderate (single samples: j = 0.44; repeated samples: j = 0.42). For NDMs, agreement was poor with single samples (j=0.16) but fair with repeated samples (j=0.25). Excluding false-negative reports from analyses improved agreement between methods in all cases except the identification of NDMs from single samples. Conclusions: Culture was three or four times more likely to report a false-negative result compared with PCR. The increased agreement between methods observed by excluding false-negative reports statistically clarifies and highlights the major discord caused by false-negative cultures. The increased agreement of NDM identification from poor to fair with repeated sampling along with their poor agreement in the single samples, with and without false-negatives, affirms the complications of NDM identification and supports the recommendation that serial samples help confirm the diagnosis of NDM infections. (J Am Podiatr Med Assoc 107(4): 280-286, 2017) Full article

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Open AccessArticle

Does Baseline Hemoglobin A_1c Level Predict Diabetic Foot Ulcer Outcome or Wound Healing Time?

by Lourdes Vella, Alfred Gatt and Cynthia Formosa

J. Am. Podiatr. Med. Assoc. 2017, 107(4), 272-279; https://doi.org/10.7547/15-176 - 1 Jul 2017

Cited by 21 | Viewed by 53

Abstract

Background: We sought to evaluate the relationship between baseline hemoglobin A1c (HbA1c) level and clinical outcomes, including foot ulcer outcome (resolved versus unresolved) and wound-healing time, in individuals with type 2 diabetes. Methods: A prospective observational study was conducted on 99 patients presenting [...] Read more.

Background: We sought to evaluate the relationship between baseline hemoglobin A1c (HbA1c) level and clinical outcomes, including foot ulcer outcome (resolved versus unresolved) and wound-healing time, in individuals with type 2 diabetes. Methods: A prospective observational study was conducted on 99 patients presenting with a diabetic foot ulceration. Patient and ulcer characteristics were recorded. Patients were followed up for a maximum of 1 year. Results: After 1 year of follow-up, 77% of ulcers healed and 23% did not heal. Although this study demonstrated that the baseline HbA1c reading was not a significant predictor of foot ulcer outcome (P = .603, resolved versus amputated), on further statistical analyses, when HbA1c was compared with the time taken for complete ulcer healing in the resolved group (n = 77), it proved to be significant (P = .009). Conclusions: These findings have important implications for clinical practice, especially in an outpatient setting. Improving glycemic control may improve ulcer outcomes. Prediction of outcome may be helpful for health-care professionals in individualizing and optimizing clinical assessment and management of patients. Identification of determinants of outcome could result in improved health outcomes, improved quality of life, and fewer diabetes-related foot complications. (J Am Podiatr Med Assoc 107(4): 272-279, 2017)
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Tedizolid and Linezolid for Treatment of Acute Bacterial Skin and Skin Structure Infections of the Lower Extremity versus Non–Lower-Extremity Infections. Pooled Analysis of Two Phase 3 Trials

by Warren S. Joseph, Darren Culshaw, Steven Anuskiewicz, Carisa De Anda and Philippe Prokocimer

J. Am. Podiatr. Med. Assoc. 2017, 107(4), 264-271; https://doi.org/10.7547/15-218 - 1 Jul 2017

Cited by 9 | Viewed by 63

Abstract

Background: Tedizolid phosphate, the prodrug of the oxazolidinone tedizolid, has been approved in a number of countries, including the United States, those in the European Union, and Canada, for treatment of patients with acute bacterial skin and skin structure infections (ABSSSI). Two phase [...] Read more.

Background: Tedizolid phosphate, the prodrug of the oxazolidinone tedizolid, has been approved in a number of countries, including the United States, those in the European Union, and Canada, for treatment of patients with acute bacterial skin and skin structure infections (ABSSSI). Two phase 3 trials demonstrated the noninferior efficacy of tedizolid (200 mg once daily for 6 days) to linezolid (600 mg twice daily for 10 days) in patients with ABSSSI. Because of the challenges of treating lower-extremity ABSSSI, the efficacy and safety of tedizolid and linezolid for treating lower-extremity versus non– lower-extremity infections were compared. Methods: This was a post hoc analysis of pooled data from patients with lower-extremity infections enrolled in two phase 3 studies, ESTABLISH-1 (NCT01170221) and ESTABLISH-2 (NCT01421511), comparing tedizolid to linezolid in patients with ABSSSI. Results: Lower-extremity ABSSSI were present in 40.7% of tedizolid-treated and 42.2% of linezolid-treated patients. Methicillin-resistant Staphylococcus aureus (MRSA) was present in 34.7% of all patients with a baseline causative pathogen. Early clinical responses at 48 to 72 hours and investigator-assessed responses at the post-therapy evaluation were similar between tedizolid and linezolid, regardless of ABSSSI type. With both treatments, the early clinical response was slightly higher in patients with non– lower-extremity infection than in those with lower-extremity ABSSSI (tedizolid, 84.8% versus 77.0%; linezolid, 81.4% versus 76.6%, respectively); however, by the posttherapy evaluation visit, response rates were similar (tedizolid, 87.1% versus 86.3%; linezolid, 86.6% versus 87.2%, respectively). Gastrointestinal adverse events and low platelet counts were observed more frequently with linezolid treatment. Conclusions: Post-therapy evaluations showed that the clinical response of lowerextremity ABSSSI to tedizolid and linezolid was comparable to that of ABSSSI in other locations. A short 6-day course of once-daily tedizolid was as effective as a 10-day course of twice-daily linezolid in treating patients with lower-extremity ABSSSI. (J Am Podiatr Med Assoc 107(4): 264-271, 2017) Full article

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J. Am. Podiatr. Med. Assoc., Volume 107, Issue 4 (07 2017) – 16 articles , Pages 264-354

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