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Current Oncology
Volume 25
Issue 6
10.3747/co.25.4188
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Incidence of Spinal Disease and Role of Spinal Radiotherapy in Multiple Myeloma

by
A.M. Sharma
1,2,
M. Sackett
2,3,
D. Bueddefeld
4,
P. Lambert
5,
A. Dubey
,
V. Wadhwa
6,
R. Kotb
2,3 and
N. Ahmed
1,2,*
1
Department of Radiation Oncology, CancerCare Manitoba, Winnipeg, MB R3E 0V9, USA
2
Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, USA
3
Department of Hematology and Oncology, CancerCare Manitoba, Winnipeg, MB R3E 0V9, USA
4
Department of Radiology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, USA
5
Department of Epidemiology, CancerCare Manitoba, Winnipeg, MB R3E 0V9, USA
6
Department of Radiology, New York–Presbyterian Hospital, New York, NY, USA
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2018, 25(6), 539-544; https://doi.org/10.3747/co.25.4188
Submission received: 5 September 2018 / Revised: 10 October 2018 / Accepted: 7 November 2018 / Published: 1 December 2018

Abstract

Background: Spinal disease (SPD) in multiple myeloma (MM) can be a major source of morbidity in newly diagnosed patients and long-term survivors. We retrospectively assessed the incidence of spinal disease in patients newly diagnosed with myeloma, its effect on survival, and the possible effect of spinal radiation therapy (RT). Methods: Patients diagnosed with MM between 2010 and 2014 were identified through the provincial cancer registry. Plain radiography, computed tomography, and magnetic resonance imaging were reviewed to detect and document the type of SPD. Data related to RT and systemic therapy were collected. Kaplan–Meier and time-varying Cox regression models were used to describe overall survival. Results: Of 306 identified patients with newly diagnosed MM, 51% had SPD, including 17% with lytic disease, 68% with compression fractures, and 15% with spinal cord compression. Of the patients with SPD, 61% received spinal RT. Of those patients, 84% received spinal RT within 3 months after their diagnosis. Median dose was 20 Gy. Most patients (89.2%) received chemotherapy, and 22.5% underwent autologous stem-cell transplantation. Only 6 of the patients treated with spinal RT received re-irradiation to the same site. Overall survival was similar for patients with and without SPD. On multivariate analysis, spinal RT had no effect on survival. Conclusions: In patients newly diagnosed with MM, SPD is a common presentation. With current systemic therapy, the presence of SPD had no adverse effect on overall survival. The effect of spinal RT on overall survival was nonsignificant.
Keywords: multiple myeloma; spinal disease; radiotherapy multiple myeloma; spinal disease; radiotherapy

Share and Cite

MDPI and ACS Style

Sharma, A.M.; Sackett, M.; Bueddefeld, D.; Lambert, P.; Dubey, A.; Wadhwa, V.; Kotb, R.; Ahmed, N. Incidence of Spinal Disease and Role of Spinal Radiotherapy in Multiple Myeloma. Curr. Oncol. 2018, 25, 539-544. https://doi.org/10.3747/co.25.4188

AMA Style

Sharma AM, Sackett M, Bueddefeld D, Lambert P, Dubey A, Wadhwa V, Kotb R, Ahmed N. Incidence of Spinal Disease and Role of Spinal Radiotherapy in Multiple Myeloma. Current Oncology. 2018; 25(6):539-544. https://doi.org/10.3747/co.25.4188

Chicago/Turabian Style

Sharma, A.M., M. Sackett, D. Bueddefeld, P. Lambert, A. Dubey, V. Wadhwa, R. Kotb, and N. Ahmed. 2018. "Incidence of Spinal Disease and Role of Spinal Radiotherapy in Multiple Myeloma" Current Oncology 25, no. 6: 539-544. https://doi.org/10.3747/co.25.4188

APA Style

Sharma, A. M., Sackett, M., Bueddefeld, D., Lambert, P., Dubey, A., Wadhwa, V., Kotb, R., & Ahmed, N. (2018). Incidence of Spinal Disease and Role of Spinal Radiotherapy in Multiple Myeloma. Current Oncology, 25(6), 539-544. https://doi.org/10.3747/co.25.4188

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