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Review

Nasopharyngeal Non-Intestinal-Type Adenocarcinoma: A Case Report and Updated Review of the Literature

by
C. Jain
1,*,
L. Caulley
2,3,
K.I. Macdonald
2,3,
B. Purgina
3,4,
C.K. Lai
3,4,
B. Esche
3,5 and
S. Johnson-Obaseki
2,3
1
Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
2
Department of Otolaryngology–Head and Neck Surgery, University of Ottawa, Ottawa, ON, Canada
3
The Ottawa Hospital, Ottawa, ON, Canada
4
Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON, Canada
5
Department of Radiation Oncology, University of Ottawa, Ottawa, ON, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2017, 24(1), 55-60; https://doi.org/10.3747/co.24.3299
Submission received: 4 November 2016 / Revised: 5 December 2016 / Accepted: 6 January 2017 / Published: 1 February 2017

Abstract

Background: Non-intestinal-type adenocarcinoma is a malignancy traditionally found in the sinonasal cavity. To our knowledge, this case is the first reported of this rare condition originating in the nasopharynx. Case Presentation: A 67-year-old woman with nasopharyngeal non-intestinal-type adenocarcinoma, with an accompanying parapharyngeal mass received primary radiation treatment for both lesions. Her tumour subsequently persisted, with a concomitant conversion in pathology from a low- to a high-grade malignancy. Results: Non-intestinal-type and intestinal-type adenocarcinomas of the nasopharynx are extremely rare tumours and do not appear in the World Health Organization classification system. We review the pathophysiologic features of these malignancies and propose modifications to the current classification system. Conclusions: Non-intestinal-type adenocarcinoma should be included in the differential diagnosis of nasopharyngeal masses. In our experience, this tumour in this location showed a partial response to primary radiation but later converted from a low- to a high-grade adenocarcinoma.
Keywords: non-intestinal adenocarcinoma; intestinal adenocarcinoma; sinonasal cavity; nasopharynx; disease classifications non-intestinal adenocarcinoma; intestinal adenocarcinoma; sinonasal cavity; nasopharynx; disease classifications

Share and Cite

MDPI and ACS Style

Jain, C.; Caulley, L.; Macdonald, K.I.; Purgina, B.; Lai, C.K.; Esche, B.; Johnson-Obaseki, S. Nasopharyngeal Non-Intestinal-Type Adenocarcinoma: A Case Report and Updated Review of the Literature. Curr. Oncol. 2017, 24, 55-60. https://doi.org/10.3747/co.24.3299

AMA Style

Jain C, Caulley L, Macdonald KI, Purgina B, Lai CK, Esche B, Johnson-Obaseki S. Nasopharyngeal Non-Intestinal-Type Adenocarcinoma: A Case Report and Updated Review of the Literature. Current Oncology. 2017; 24(1):55-60. https://doi.org/10.3747/co.24.3299

Chicago/Turabian Style

Jain, C., L. Caulley, K.I. Macdonald, B. Purgina, C.K. Lai, B. Esche, and S. Johnson-Obaseki. 2017. "Nasopharyngeal Non-Intestinal-Type Adenocarcinoma: A Case Report and Updated Review of the Literature" Current Oncology 24, no. 1: 55-60. https://doi.org/10.3747/co.24.3299

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