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Current Oncology
Volume 20
Issue 6
10.3747/co.20.1485
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Superficial Parotid Lobe–Sparing Delineation Approach: A Better Method of Dose Optimization to Protect the Parotid Gland in Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma

by
H.B. Zhang
1,†,
X. Lu
1,†,
S.M. Huang
2,
L. Wang
1,
C. Zhao
2,
W.X. Xia
1,
S.W. Li
1,
F.L. Wang
1,
Y.L. Zhu
1,
X. Guo
1,* and
Y.Q. Xiang
1,*
1
Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
2
Department of Radiotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China
3
These authors contributed equally to the present work.
*
Authors to whom correspondence should be addressed.
Curr. Oncol. 2013, 20(6), 577-584; https://doi.org/10.3747/co.20.1485
Submission received: 7 September 2013 / Revised: 9 October 2013 / Accepted: 10 November 2013 / Published: 1 December 2013

Abstract

Purpose: We used a superficial parotid lobe–sparing delineation approach for dose optimization with better protection for the parotid glands in intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC) patients. Methods: Compared with traditional contouring of the entire parotid glands as organs at risk (OARS) in IMRT for NPC, we used a superficial parotid lobe–sparing delineation approach of contouring the superficial parotid lobes as OARS. Changes in dose to the parotid glands, the targets, and other OARS were evaluated. Results: The mean dose to the parotid glands overall decreased by more than 4 Gy in the test plans. Impressively, the mean dose to the superficial parotid lobes in the test plans was not more than 30 Gy, regardless of clinical stage. In T1–3 NPC patients, the dose distributions for targets were not significantly different in the control plans and the test plans. However, for some T4 patients, the dose distributions for targets and brainstem in the test plans could not meet clinical requirements. Conclusions: The superficial parotid lobe–sparing delineation approach can significantly lower the mean dose to the entire parotid and to the superficial parotid lobe in T1–3 NPC patients, which would be expected to result in less xerostomia and better quality of life for those patients.
Keywords: intensity-modulated radiotherapy; nasopharyngeal carcinoma; superficial parotid lobes intensity-modulated radiotherapy; nasopharyngeal carcinoma; superficial parotid lobes

Share and Cite

MDPI and ACS Style

Zhang, H.B.; Lu, X.; Huang, S.M.; Wang, L.; Zhao, C.; Xia, W.X.; Li, S.W.; Wang, F.L.; Zhu, Y.L.; Guo, X.; et al. Superficial Parotid Lobe–Sparing Delineation Approach: A Better Method of Dose Optimization to Protect the Parotid Gland in Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma. Curr. Oncol. 2013, 20, 577-584. https://doi.org/10.3747/co.20.1485

AMA Style

Zhang HB, Lu X, Huang SM, Wang L, Zhao C, Xia WX, Li SW, Wang FL, Zhu YL, Guo X, et al. Superficial Parotid Lobe–Sparing Delineation Approach: A Better Method of Dose Optimization to Protect the Parotid Gland in Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma. Current Oncology. 2013; 20(6):577-584. https://doi.org/10.3747/co.20.1485

Chicago/Turabian Style

Zhang, H.B., X. Lu, S.M. Huang, L. Wang, C. Zhao, W.X. Xia, S.W. Li, F.L. Wang, Y.L. Zhu, X. Guo, and et al. 2013. "Superficial Parotid Lobe–Sparing Delineation Approach: A Better Method of Dose Optimization to Protect the Parotid Gland in Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma" Current Oncology 20, no. 6: 577-584. https://doi.org/10.3747/co.20.1485

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