Abstract
Guidelines on the management of metastatic renal cell carcinoma (RCC) have emerged over the last couple of years because of the introduction of effective new targeted therapies. However, current guidelines are not always contemporary because of older data whose relevance is unclear in the context of the new therapies. Moreover, many of the relevant trials were interrupted prematurely because of significant advantages in progression-free survival. These circumstances sometimes make interpretation of the data and characterization of subgroups rather difficult. The current paper reviews the major guidelines available on the management of metastatic RCC and tries to put them into context.