Abstract
We present the diagnostic pathway and management of an asymptomatic patient with a solitary, potentially high-risk coronary plaque, utilizing modern and advanced non-invasive and invasive pathophysiological, morphological, and functional assessment. By using coronary computed to mography angiography, computer-based solutions were employed enabling non-invasive under standing of the plaque characteristics and the local and global functional micro-environment. Invasive coronary angiography-based, computational, and wire-free hemodynamic lesion assess ment as well as intracoronary imaging with optical coherence tomography were further utilized, allowing for personalized management and guiding coronary revascularization.