Association between Low-Dose Computed Tomography Results and 1-Year Smoking Cessation in a Residential Smoking Cessation Program
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Participants
2.2. Measurements
2.3. Intervention and Follow-Up
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variables | 6 Months | p-Value | 12 Months | p-Value | ||
---|---|---|---|---|---|---|
Success | Fail | Success | Fail | |||
179 (61.3) | 113 (38.7) | 92 (31.5) | 200 (68.5) | |||
Age (yr, mean ± SD) | 55.38 (10.46) | 55.02 (11.16) | 0.779 | 53.87 (9.67) | 55.87 (11.14) | 0.139 |
Sex | 0.113 | 0.092 | ||||
Men | 169 (94.4) | 101 (89.4) | 89 (96.7) | 181 (90.5) | ||
Women | 10 (5.6) | 12 (10.6) | 3 (3.3) | 19 (9.5) | ||
Education level | 0.022 | 0.451 | ||||
Middle school or less | 14 (7.8) | 21 (18.6) | 8 (8.7) | 27 (13.5) | ||
High school | 70 (39.1) | 38 (33.6) | 37 (40.2) | 71 (35.5) | ||
College or beyond | 95 (53.1) | 54 (47.8) | 47 (51.1) | 102 (51.0) | ||
Alcohol consumption | 0.777 | 0.433 | ||||
Yes | 92 (51.4) | 60 (53.1) | 51 (55.4) | 101 (50.5) | ||
Regular Exercise | 0.023 | 0.571 | ||||
Yes | 69 (38.5) | 29 (25.7) | 33 (35.9) | 65 (32.5) | ||
Hypertension | 52 (29.1) | 40 (35.4) | 0.255 | 27 (29.3) | 65 (32.5) | 0.590 |
Diabetes Mellitus | 32 (17.9) | 22 (19.5) | 0.733 | 14 (15.2) | 40 (20.0) | 0.328 |
Dyslipidemia | 53 (29.6) | 20 (17.7) | 0.022 | 29 (31.5) | 44 (22.0) | 0.081 |
Coronary artery disease | 13 (7.3) | 12 (10.6) | 0.318 | 8 (8.7) | 17 (8.5) | 0.956 |
Cerebrovascular disease | 11 (6.1) | 1 (0.9) | 0.033 | 8 (8.7) | 4 (2.0) | 0.011 |
Cancer | 12 (6.7) | 7 (6.2) | 0.864 | 6 (6.5) | 13 (6.5) | 0.994 |
Psychiatric disease | 37 (20.7) | 91 (80.5) | <0.001 | 7 (7.6) | 121 (60.5) | <0.001 |
Smoking pack-years (mean ± SD) | 35.84 (14.19) | 40.92 (19.99) | 0.020 | 35.79 (11.54) | 38.73 (18.72) | 0.102 |
FTND (a) score | 0.016 | 0.665 | ||||
0 | 3 (1.7) | 2 (1.8) | 1 (1.1) | 4 (2.0) | ||
Mild [1,2,3] | 65 (36.3) | 22 (19.5) | 26 (28.3) | 61 (30.5) | ||
Moderate [4,5,6] | 68 (38.0) | 53 (46.9) | 43 (46.7) | 78 (39.0) | ||
Severe [7,8,9,10] | 43 (24.0) | 36 (31.9) | 22 (23.9) | 57 (28.5) | ||
Pharmacotherapy | 0.275 | 0.233 | ||||
No | 8 (4.5) | 5 (4.4) | 1 (1.1) | 12 (6.0) | ||
NRT (b) | 67 (37.4) | 49 (43.4) | 41 (44.6) | 75 (37.5) | ||
Varenicline | 6 (3.4) | 8 (7.1) | 4 (4.3) | 10 (5.0) | ||
Varenicline + short term NRT (b) | 98 (54.7) | 51 (45.1) | 46 (50.0) | 103 (51.5) |
Variables | 6 Months | p-Value | 12 Months | p-Value | ||
---|---|---|---|---|---|---|
Success | Fail | Success | Fail | |||
179 (61.3) | 113 (38.7) | 92 (31.5) | 200 (68.5) | |||
Low-dose computed tomography | ||||||
Nodule | 0.001 | <0.001 | ||||
Negative | 93 (52.0) | 63 (55.8) | 43 (46.7) | 113 (56.5) | ||
Benign | 59 (33.0) | 47 (41.6) | 27 (29.3) | 79 (39.5) | ||
Indeterminate or suspicious malignancy | 27 (15.1) | 3 (2.7) | 22 (23.9) | 8 (4.0) | ||
Emphysema | 49 (27.4) | 36 (32.1) | 0.384 | 20 (21.7) | 65 (32.7) | 0.057 |
Interstitial lung disease | 7 (3.9) | 0 | 0.046 | 2 (2.2) | 5 (2.5) | 1.000 |
Extrapulmonary neoplasm | 7 (3.9) | 1 (0.9) | 0.157 | 4 (4.3) | 4 (2.0) | 0.266 |
Coronary artery calcification | 56 (31.3) | 22 (19.5) | 0.026 | 20 (21.7) | 58 (29.0) | 0.193 |
Variables | Unadjusted | Model 1 | Model 2 | |||
---|---|---|---|---|---|---|
OR | 95% CI | OR | 95% CI | OR | 95% CI | |
Age | 1.00 | (0.98–1.03) | 1.00 | (0.9–1.03) | 1.03 | (1.00–1.06) |
Sex | ||||||
Men | 1 | 1 | 1 | |||
Women | 0.50 | (0.21–1.19) | 0.50 | (0.21–1.19) | 1.67 | (0.55–5.16) |
Education level | ||||||
Middle school or less | 1 | 1 | 1 | |||
High school | 2.76 | (1.26–6.05) | 3.16 | (1.36–7.33) | 4.39 | (1.36–14.14) |
College or beyond | 2.64 | (1.21–5.61) | 3.12 | (1.34–7.28) | 4.37 | (1.36–14.08) |
Regular Exercise | ||||||
Yes | 1.82 | (1.08–3.05) | 1.79 | (1.07–3.02) | 2.41 | (1.22–4.76) |
Dyslipidemia | 1.96 | (1.10–3.49) | 2.01 | (1.12–3.61) | 1.77 | (0.80–3.96) |
Cerebrovascular disease | 7.33 | (0.93–57.60) | 6.90 | (0.88–54.40) | 8.50 | (0.75–96.11) |
Psychiatric disease | 0.06 | (0.04–0.11) | 0.06 | (0.03–0.11) | 0.06 | (0.03–0.12) |
FTND (a) score | 0.98 | (0.97–0.99) | 0.88 | (0.80–0.98) | 0.88 | (0.77–1.00) |
Low-dose computed tomography | ||||||
Nodule | ||||||
Negative | 1 | 1 | 1 | |||
Benign | 0.85 | (0.52–1.40) | 0.80 | (0.48–1.35) | 0.79 | (0.40–1.57) |
Indeterminate or suspicious malignancy | 6.10 | (1.77–20.96) | 5.67 | (1.64–19.59) | 1.31 | (0.34–5.12) |
Coronary artery calcification | 1.88 | (1.07–3.31) | 1.94 | (1.08–3.50) | 1.91 | (0.89–4.12) |
Variables | Unadjusted | Model 1 | Model 2 | |||
---|---|---|---|---|---|---|
OR | 95% CI | OR | 95% CI | OR | 95% CI | |
Age | 0.98 | (0.96–1.01) | 0.98 | (0.96–1.01) | 0.99 | (0.96–1.24) |
Sex | ||||||
Men | 1 | 1 | 1 | |||
Women | 0.32 | (0.09–1.11) | 0.33 | (0.09–1.04) | 0.60 | (0.14–2.62) |
Cerebrovascular disease | 4.67 | (1.37–15.92) | 4.82 | (1.40–16.68) | 3.24 | (0.77–13.63) |
Psychiatric disease | 0.05 | (0.02–0.12) | 0.06 | (0.02–0.13) | 0.06 | (0.03–0.15) |
FTND (a) score | 0.93 | (0.90–1.10) | 1.01 | (0.91–1.13) | 1.09 | (0.96–1.24) |
Nodule | ||||||
Negative | 1 | 1 | 1 | |||
Benign | 0.90 | (0.51–1.57) | 0.99 | (0.55–1.78) | 1.03 | (0.53–2.01) |
Indeterminate or suspicious malignancy | 7.23 | (2.99–17.46) | 7.25 | (2.95–17.81) | 3.02 | (1.15–7.98) |
Emphysema | 0.57 | (0.32–1.02) | 0.58 | (0.32–1.07) | 0.58 | (0.28–1.19) |
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Shin, D.-S.; Noh, H.-M.; Song, H.J.; Park, K.H.; Seo, Y.-G.; Paek, Y.-J. Association between Low-Dose Computed Tomography Results and 1-Year Smoking Cessation in a Residential Smoking Cessation Program. Int. J. Environ. Res. Public Health 2022, 19, 5510. https://doi.org/10.3390/ijerph19095510
Shin D-S, Noh H-M, Song HJ, Park KH, Seo Y-G, Paek Y-J. Association between Low-Dose Computed Tomography Results and 1-Year Smoking Cessation in a Residential Smoking Cessation Program. International Journal of Environmental Research and Public Health. 2022; 19(9):5510. https://doi.org/10.3390/ijerph19095510
Chicago/Turabian StyleShin, Da-Som, Hye-Mi Noh, Hong Ji Song, Kyung Hee Park, Young-Gyun Seo, and Yu-Jin Paek. 2022. "Association between Low-Dose Computed Tomography Results and 1-Year Smoking Cessation in a Residential Smoking Cessation Program" International Journal of Environmental Research and Public Health 19, no. 9: 5510. https://doi.org/10.3390/ijerph19095510