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Open AccessArticle

Diversity of Oxacillinases and Sequence Types in Carbapenem-Resistant Acinetobacter baumannii from Austria

1
D&R Institute of Hygiene, Microbiology and Environmental Medicine, Neue Stiftingtalstrasse 6, A-8010 Graz, Austria
2
Department of Microbiology, University Hospital Center Zagreb, 10000 Zagreb, Croatia
3
Department of Infection Control and Hospital Epidemiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria
4
Institute of Hygiene and Microbiology, Medical University Innsbruck, Schöpfstrasse 41, A-6020 Innsbruck, Austria
5
Hospital Rudolfstiftung, Juchgasse 25, 1030 Wien, Austria
*
Author to whom correspondence should be addressed.
Academic Editor: Paul Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(4), 2171; https://doi.org/10.3390/ijerph18042171
Received: 11 January 2021 / Revised: 17 February 2021 / Accepted: 18 February 2021 / Published: 23 February 2021
(This article belongs to the Section Infectious Disease Epidemiology)
Carbapenem-resistant Acinetobacter baumannii is a significant health problem worldwide. A multicenter study on A. baumannii was performed to investigate the molecular epidemiology and genetic background of carbapenem resistance of A. baumannii isolates collected from 2014–2017 in Austria. In total, 117 non-repetitive Acinetobacter spp. assigned to A. baumannii (n = 114) and A. pittii (n = 3) were collected from four centers in Austria. The isolates were uniformly resistant to piperacillin/tazobactam, ceftazidime, and carbapenems, and resistance to imipenem and meropenem was 97.4% and 98.2%, respectively. The most prominent OXA-types were OXA-58-like (46.5%) and OXA-23-like (41.2%), followed by OXA-24-like (10.5%), with notable regional differences. Carbapenem-hydrolyzing class D carbapenemases (CHDLs) were the only carbapenemases found in A.baumannii isolates in Austria since no metallo-β-lactamases (MBLs) nor KPC or GES carbapenemases were detected in any of the isolates. One-third of the isolates harbored multiple CHDLs. The population structure of A. baumannii isolates from Austria was found to be very diverse, while a total of twenty-three different sequence types (STs) were identified. The most frequent was ST195 found in 15.8%, followed by ST218 and ST231 equally found in 11.4% of isolates. Two new ST types, ST2025 and ST2026, were detected. In one A. pittii isolate, blaOXA-143-like was detected for the first time in Austria. View Full-Text
Keywords: Acinetobacter baumannii; Acinetobacter pittii; OXA carbapenemases; OXA-143; OXA-23; meropenem; imipenem Acinetobacter baumannii; Acinetobacter pittii; OXA carbapenemases; OXA-143; OXA-23; meropenem; imipenem
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MDPI and ACS Style

Grisold, A.J.; Luxner, J.; Bedenić, B.; Diab-Elschahawi, M.; Berktold, M.; Wechsler-Fördös, A.; Zarfel, G.E. Diversity of Oxacillinases and Sequence Types in Carbapenem-Resistant Acinetobacter baumannii from Austria. Int. J. Environ. Res. Public Health 2021, 18, 2171. https://doi.org/10.3390/ijerph18042171

AMA Style

Grisold AJ, Luxner J, Bedenić B, Diab-Elschahawi M, Berktold M, Wechsler-Fördös A, Zarfel GE. Diversity of Oxacillinases and Sequence Types in Carbapenem-Resistant Acinetobacter baumannii from Austria. International Journal of Environmental Research and Public Health. 2021; 18(4):2171. https://doi.org/10.3390/ijerph18042171

Chicago/Turabian Style

Grisold, Andrea J.; Luxner, Josefa; Bedenić, Branka; Diab-Elschahawi, Magda; Berktold, Michael; Wechsler-Fördös, Agnes; Zarfel, Gernot E. 2021. "Diversity of Oxacillinases and Sequence Types in Carbapenem-Resistant Acinetobacter baumannii from Austria" Int. J. Environ. Res. Public Health 18, no. 4: 2171. https://doi.org/10.3390/ijerph18042171

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