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Article

Cerebrospinal Fluid Protein Concentration in Healthy Older Japanese Volunteers

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SOUSEIKAI Fukuoka Mirai Hospital Clinical Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan
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Department of Public Health, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan
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SOUSEIKAI Clinical Epidemiological Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan
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College of Healthcare Management, Takayanagi 960-4, Setaka-machi, Miyama 835-0018, Japan
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SOUSEIKAI Sumida Hospital, 1-29-1, Honjo, Sumida-ku, Tokyo 130-0004, Japan
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SOUSEIKAI Global Clinical Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(16), 8683; https://doi.org/10.3390/ijerph18168683
Received: 22 May 2021 / Revised: 13 August 2021 / Accepted: 15 August 2021 / Published: 17 August 2021
The concentration of cerebrospinal fluid total protein (CSF-TP) is important for the diagnosis of neurological emergencies. Recently, some Western studies have shown that the current upper reference limit of CSF-TP is quite low for older patients. However, little is reported about the concentration of CSF-TP in the older Asian population. In this study, we retrospectively analyzed the CSF-TP concentrations in healthy older Japanese volunteers. CSF samples in 69 healthy Japanese volunteers (age range: 55–73 years) were collected by lumbar puncture, and the data of CSF were retrospectively analyzed. The mean (standard deviation) CSF-TP was 41.7 (12.3) mg/dL. The older group (≥65 years old) had higher CSF-TP concentration than the younger group (55–64 years old). The 2.5th percentile and 97.5th percentile of CSF-TP were estimated as 22.5 and 73.2 mg/dL, respectively, which were higher than the current reference range in Japan (10–40 mg/dL). Conclusions: The reference interval of CSF-TP in the older population should be reconsidered for the precise diagnosis of neurological emergencies. View Full-Text
Keywords: cerebrospinal fluid; total protein; reference interval; older population; Japanese healthy volunteer cerebrospinal fluid; total protein; reference interval; older population; Japanese healthy volunteer
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MDPI and ACS Style

Yoshihara, T.; Zaitsu, M.; Ito, K.; Hanada, R.; Chung, E.; Yazawa, R.; Sakata, Y.; Furusho, K.; Tsukikawa, H.; Chiyoda, T.; Matsuki, S.; Irie, S. Cerebrospinal Fluid Protein Concentration in Healthy Older Japanese Volunteers. Int. J. Environ. Res. Public Health 2021, 18, 8683. https://doi.org/10.3390/ijerph18168683

AMA Style

Yoshihara T, Zaitsu M, Ito K, Hanada R, Chung E, Yazawa R, Sakata Y, Furusho K, Tsukikawa H, Chiyoda T, Matsuki S, Irie S. Cerebrospinal Fluid Protein Concentration in Healthy Older Japanese Volunteers. International Journal of Environmental Research and Public Health. 2021; 18(16):8683. https://doi.org/10.3390/ijerph18168683

Chicago/Turabian Style

Yoshihara, Tatsuya, Masayoshi Zaitsu, Kazuya Ito, Ryuzo Hanada, Eunhee Chung, Rie Yazawa, Yukikuni Sakata, Koki Furusho, Hiroshi Tsukikawa, Takeshi Chiyoda, Shunji Matsuki, and Shin Irie. 2021. "Cerebrospinal Fluid Protein Concentration in Healthy Older Japanese Volunteers" International Journal of Environmental Research and Public Health 18, no. 16: 8683. https://doi.org/10.3390/ijerph18168683

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