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Int. J. Environ. Res. Public Health 2015, 12(2), 1998-2008;

Body Mass Index (BMI) Is Associated with Microalbuminuria in Chinese Hypertensive Patients

Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China
Department of Statistics, School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, China
Clinical Laboratory Centre, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
Centre for Bio Analytical Sciences (CBAS), Dublin City University, Dublin 9, Ireland
Techco Information Technologies Co., Ltd., Shenzhen 518057, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 21 November 2014 / Accepted: 30 January 2015 / Published: 10 February 2015
Full-Text   |   PDF [683 KB, uploaded 11 February 2015]   |  


There is no general consensus on possible factors associated with microalbuminuria in hypertensive patients nor any reported study about this issue in Chinese patients. To examine this issues, 944 hypertensive patients were enrolled in a study based on a cross-sectional survey conducted in Southern China. Multivariate regression analyses were performed to identify the factors related with the presence of microalbuminuria and urinary excretion of albumin. The prevalence of microalbuminuria in hypertensive and non-diabetic hypertensive patients were 17.16% and 15.25%, respectively. Body mass index (BMI), but not waist circumference (WC), were independently associated with microalbuminuria and the values of urinary albumin to creatinine ratio (ACR) based on multiple regression analyses, even after excluding diabetic patients and patients taking inhibitors of the renin-angiotensin system from the analyses. Furthermore, patients with obesity (BMI ≥28) had higher levels of ACR, compared with those with normal weight (BMI <24 kg/m2) and overweight (24 kg/m2≤ BMI < 28). In conclusion, BMI, as a modifiable factor, is closely associated with microalbuminuria among Chinese hypertensive patients, which may provide a basis for future development of intervention approaches for these patients. View Full-Text
Keywords: hypertension; mircroalbuminuria; BMI hypertension; mircroalbuminuria; BMI

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Liu, X.; Liu, Y.; Chen, Y.; Li, Y.; Shao, X.; Liang, Y.; Li, B.; Holthöfer, H.; Zhang, G.; Zou, H. Body Mass Index (BMI) Is Associated with Microalbuminuria in Chinese Hypertensive Patients. Int. J. Environ. Res. Public Health 2015, 12, 1998-2008.

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