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Open AccessCommunication
Mar. Drugs 2018, 16(5), 150; https://doi.org/10.3390/md16050150

Two New Terpenoids from Talaromyces purpurogenus

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
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Received: 30 March 2018 / Revised: 23 April 2018 / Accepted: 27 April 2018 / Published: 2 May 2018
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Abstract

A new sesquiterpenoid 9,10-diolhinokiic acid (1) and a new diterpenoid roussoellol C (2), together with 4 known compounds, were isolated from the extracts of laboratory cultures of marine-derived fungus Talaromyces purpurogenus. 9,10-diolhinokiic acid is the first thujopsene-type sesquiterpenoid containing a 9,10-diol moiety, and roussoellol C possesses a novel tetracyclic fusicoccane framework with an unexpected hydroxyl at C-4. These new structures were confirmed by spectroscopic data, chemical method, NMR data calculations and electronic circular dichroism (ECD) calculations. The selected compounds were evaluated for cytotoxicities against five human cancer cell lines, including SW480, HL-60, A549, MCF-7, and SMMC-7721 and the IC50 values of compound 2 against MCF-7 and 3 against HL-60 cells were 6.5 and 7.9 μM, respectively. View Full-Text
Keywords: sesquiterpenoid; diterpenoid; Talaromyces purpurogenus; NMR data calculations; ECD calculations; cytotoxicities sesquiterpenoid; diterpenoid; Talaromyces purpurogenus; NMR data calculations; ECD calculations; cytotoxicities
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Wang, W.; Wan, X.; Liu, J.; Wang, J.; Zhu, H.; Chen, C.; Zhang, Y. Two New Terpenoids from Talaromyces purpurogenus. Mar. Drugs 2018, 16, 150.

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