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Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79

Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
College of Earth Science, University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China
Author to whom correspondence should be addressed.
Academic Editors: Vítor Vasconcelos, Pedro Leão and Anake Kijjoa
Mar. Drugs 2017, 15(5), 137;
Received: 8 February 2017 / Revised: 24 March 2017 / Accepted: 10 May 2017 / Published: 12 May 2017
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes - II)
PDF [1814 KB, uploaded 12 May 2017]


Three new indolediterpenoids, namely, 22-hydroxylshearinine F (1), 6-hydroxylpaspalinine (2), and 7-O-acetylemindole SB (3), along with eight related known analogs (411), were isolated from the sea-anemone-derived fungus Penicillium sp. AS-79. The structures and relative configurations of these compounds were determined by a detailed interpretation of the spectroscopic data, and their absolute configurations were determined by ECD calculations (1 and 2) and single-crystal X-ray diffraction (3). Some of these compounds exhibited prominent activity against aquatic and human pathogenic microbes. View Full-Text
Keywords: endophytic fungus; Penicillium sp.; secondary metabolites; antimicrobial activity endophytic fungus; Penicillium sp.; secondary metabolites; antimicrobial activity

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Hu, X.-Y.; Meng, L.-H.; Li, X.; Yang, S.-Q.; Li, X.-M.; Wang, B.-G. Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79. Mar. Drugs 2017, 15, 137.

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