Next Article in Journal
New Polyketides and New Benzoic Acid Derivatives from the Marine Sponge-Associated Fungus Neosartorya quadricincta KUFA 0081
Previous Article in Journal
Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Show Cytotoxic Properties and Prevent EGF-Induced Neoplastic Transformation in Vitro
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2016, 14(7), 132;

Chamigrane Sesquiterpenes from a Basidiomycetous Endophytic Fungus XG8D Associated with Thai Mangrove Xylocarpus granatum

The United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
Faculty of Science and Technology, Valaya Alongkorn Rajabhat University under Royal Patronage, Pathumtani 13138, Thailand
Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 25 May 2016 / Revised: 5 July 2016 / Accepted: 6 July 2016 / Published: 15 July 2016
Full-Text   |   PDF [1845 KB, uploaded 15 July 2016]   |  


Six new chamigrane sesquiterpenes, merulinols A‒F (16), and four known metabolites (710) were isolated from the culture of the basidiomycetous fungus XG8D, a mangrove-derived endophyte. Their structures were elucidated mainly by 1D and 2D NMR, while the structures of 1 and 2 were further confirmed by single-crystal X-ray diffraction analysis. The in vitro cytotoxicity of all compounds was evaluated against three human cancer cell lines, MCF-7, Hep-G2, and KATO-3. Compounds 3 and 4 selectively displayed cytotoxicity against KATO-3 cells with IC50 values of 35.0 and 25.3 μM, respectively. View Full-Text
Keywords: chamigrane; sesquiterpene; endophytic fungus; cytotoxic chamigrane; sesquiterpene; endophytic fungus; cytotoxic

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Choodej, S.; Teerawatananond, T.; Mitsunaga, T.; Pudhom, K. Chamigrane Sesquiterpenes from a Basidiomycetous Endophytic Fungus XG8D Associated with Thai Mangrove Xylocarpus granatum. Mar. Drugs 2016, 14, 132.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top