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Open AccessArticle

Dihydroisocoumarins from the Mangrove-Derived Fungus Penicillium citrinum

Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Russell Kerr
Mar. Drugs 2016, 14(10), 177;
Received: 3 August 2016 / Revised: 17 September 2016 / Accepted: 28 September 2016 / Published: 10 October 2016
(This article belongs to the Special Issue Marine Fungal Natural Products)
PDF [1781 KB, uploaded 10 October 2016]


Three new dihydroisocoumarin penicimarins G–I (13), together with one known dihydroisocoumarin (4) and three known meroterpenoids (57), were obtained from a fungus Penicillium citrinum isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Their structures were elucidated by the detailed analysis of spectroscopic data. The absolute configuration of 1 was determined by the X-ray diffraction analysis using Cu Kα radiation. The absolute configurations of 2 and 3 were determined by comparison of their circular dichroism (CD) spectra with the literature. All compounds were evaluated for their antibacterial activities and cytotoxic activities. View Full-Text
Keywords: Penicillium citrinum; metabolites; dihydroisocoumarin; antibacterial activity; cytotoxic activity Penicillium citrinum; metabolites; dihydroisocoumarin; antibacterial activity; cytotoxic activity

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Huang, G.-L.; Zhou, X.-M.; Bai, M.; Liu, Y.-X.; Zhao, Y.-L.; Luo, Y.-P.; Niu, Y.-Y.; Zheng, C.-J.; Chen, G.-Y. Dihydroisocoumarins from the Mangrove-Derived Fungus Penicillium citrinum. Mar. Drugs 2016, 14, 177.

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