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Open AccessReview

Marine Peptides and Their Anti-Infective Activities

Department of Biomedical Science, Chosun University, Gwangju 501-759, Korea
Department of Bioinformatics, Kongju National University, Kongju 314-701, Korea
Research Center for Proteineous Materials, Chosun University, Gwangju 501-759, Korea
Author to whom correspondence should be addressed.
Academic Editor: Miguel O. Mitchell
Mar. Drugs 2015, 13(1), 618-654;
Received: 11 November 2014 / Accepted: 1 January 2015 / Published: 16 January 2015
(This article belongs to the Special Issue Marine Anti-infective Agents)
PDF [1268 KB, uploaded 24 February 2015]


Marine bioresources are a valuable source of bioactive compounds with industrial and nutraceutical potential. Numerous clinical trials evaluating novel chemotherapeutic agents derived from marine sources have revealed novel mechanisms of action. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities. In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites. However, the treatments available for many infectious diseases caused by bacteria, fungi, and viruses are limited. Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored. In this review, we will present the structures and anti-infective activity of peptides isolated from marine sources (sponges, algae, bacteria, fungi and fish) from 2006 to the present. View Full-Text
Keywords: marine organisms; anti-infective peptides; antimicrobial; antifungal; antiviral marine organisms; anti-infective peptides; antimicrobial; antifungal; antiviral

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kang, H.K.; Seo, C.H.; Park, Y. Marine Peptides and Their Anti-Infective Activities. Mar. Drugs 2015, 13, 618-654.

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