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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Exploring Biochemistry and Cellular Biology with Protein Libraries

by
Juan E. Diaz
1,
Brett E. Howard
2,
Marc S. Neubauer
2,
Allison Olszewski
2 and
Gregory A. Weiss
1,2,*
1
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-2025, USA
2
Department of Chemistry, University of California, Irvine, CA 92697-2025, USA
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2003, 5(4), 129-146; https://doi.org/10.21775/cimb.005.129
Submission received: 7 May 2003 / Revised: 2 August 2003 / Accepted: 7 September 2003 / Published: 1 October 2003
Versions Notes

Abstract

Polypeptide libraries cast a broad net for defining enzyme and binding protein specificities. In addition to uncovering rules for molecular recognition, the binding preferences and functional group tolerances from such libraries can reveal mechanisms underlying biochemical and cellular processes. Ligands obtained from protein libraries can also provide pharmaceutical lead compounds and even reagents to further explore cell biology. Here, we review selected recent examples of protein libraries demonstrating these principles. In particular, we focus on combinatorial libraries composed of randomized peptides or variations of a single protein. The characteristics of various techniques for library constructions and screening are also briefly surveyed.
Keywords: polypeptide libraries; binding protein; molecular recognition; binding preferences; ligands; protein libraries; combinatorial libraries; library polypeptide libraries; binding protein; molecular recognition; binding preferences; ligands; protein libraries; combinatorial libraries; library

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MDPI and ACS Style

Diaz, J.E.; Howard, B.E.; Neubauer, M.S.; Olszewski, A.; Weiss, G.A. Exploring Biochemistry and Cellular Biology with Protein Libraries. Curr. Issues Mol. Biol. 2003, 5, 129-146. https://doi.org/10.21775/cimb.005.129

AMA Style

Diaz JE, Howard BE, Neubauer MS, Olszewski A, Weiss GA. Exploring Biochemistry and Cellular Biology with Protein Libraries. Current Issues in Molecular Biology. 2003; 5(4):129-146. https://doi.org/10.21775/cimb.005.129

Chicago/Turabian Style

Diaz, Juan E., Brett E. Howard, Marc S. Neubauer, Allison Olszewski, and Gregory A. Weiss. 2003. "Exploring Biochemistry and Cellular Biology with Protein Libraries" Current Issues in Molecular Biology 5, no. 4: 129-146. https://doi.org/10.21775/cimb.005.129

APA Style

Diaz, J. E., Howard, B. E., Neubauer, M. S., Olszewski, A., & Weiss, G. A. (2003). Exploring Biochemistry and Cellular Biology with Protein Libraries. Current Issues in Molecular Biology, 5(4), 129-146. https://doi.org/10.21775/cimb.005.129

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