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Volume 35
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10.21775/cimb.035.195
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Ubiquitination and SUMOylation of Amyloid and Amyloid-Like Proteins in Health and Disease

by
Lenzie Ford
1,2,3,
Luana Fioriti
4,5 and
Eric R. Kandel
1,2,3,6,*
1
Department of Neuroscience, Columbia University, New York, NY, USA
2
Howard Hughes Medical Institute, Chevy Chase, MD, USA
3
Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA
4
Istituto di Ricerche Farmacologiche Mario Negri, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
5
Dulbecco Telethon Institute, Fondazione Telethon, Rome, Italy
6
Kavli Institute for Brain Science, Columbia University, New York, NY, USA
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2020, 35(1), 195-230; https://doi.org/10.21775/cimb.035.195
Submission received: 23 May 2019 / Revised: 5 June 2019 / Accepted: 18 July 2019 / Published: 18 August 2019
Versions Notes

Abstract

Post-translational modifications (PTMs) play important roles in altering the structure and function of proteins. In this article, we focus on ubiquitination and SUMOylation of amyloidogenic proteins. We discuss the functional contributions of PTMs on proteins involved in amyloid-related diseases as well as the aberrant PTM signatures of the disease agents. In addition, we extend our discussion to the nascent field of functional amyloids, a subclass of amyloids that perform physiological functions. Here, we present examples from mammals and yeast to gain insight into physiological regulation of amyloid-like proteins.

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MDPI and ACS Style

Ford, L.; Fioriti, L.; Kandel, E.R. Ubiquitination and SUMOylation of Amyloid and Amyloid-Like Proteins in Health and Disease. Curr. Issues Mol. Biol. 2020, 35, 195-230. https://doi.org/10.21775/cimb.035.195

AMA Style

Ford L, Fioriti L, Kandel ER. Ubiquitination and SUMOylation of Amyloid and Amyloid-Like Proteins in Health and Disease. Current Issues in Molecular Biology. 2020; 35(1):195-230. https://doi.org/10.21775/cimb.035.195

Chicago/Turabian Style

Ford, Lenzie, Luana Fioriti, and Eric R. Kandel. 2020. "Ubiquitination and SUMOylation of Amyloid and Amyloid-Like Proteins in Health and Disease" Current Issues in Molecular Biology 35, no. 1: 195-230. https://doi.org/10.21775/cimb.035.195

APA Style

Ford, L., Fioriti, L., & Kandel, E. R. (2020). Ubiquitination and SUMOylation of Amyloid and Amyloid-Like Proteins in Health and Disease. Current Issues in Molecular Biology, 35(1), 195-230. https://doi.org/10.21775/cimb.035.195

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