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Volume 25
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10.21775/cimb.025.081
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Manipulation of Autophagy by Bacterial Pathogens Impacts Host Immunity

by
Tobias C. Kunz
1,2,
Flávia Viana
1,2,
Carmen Buchrieser
1,2,* and
Pedro Escoll
1,2,*
1
Institut Pasteur, Biologie des Bactéries Intracellulaires, Paris, France
2
Centre National de la Recherche Scientifique (CNRS) UMR 3525, Paris, France
*
Authors to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2018, 25(1), 81-98; https://doi.org/10.21775/cimb.025.081
Submission received: 6 June 2017 / Revised: 7 July 2017 / Accepted: 14 August 2017 / Published: 6 September 2017

Abstract

Autophagy is a highly conserved catabolic process, degrading unnecessary or damaged components in the eukaryotic cell to maintain cellular homeostasis, but it is also an intrinsic cellular defence mechanism to remove invading pathogens. A cross-talk between autophagy and innate or adaptive immune responses has been recently reported, whereby autophagy influences both innate and adaptive immunity, like the production and secretion of proinflammatory cytokines or MHC class II antigen presentation to T cells. Pathogenic bacteria have evolved diverse strategies to manipulate autophagy, mechanisms that also impact host immune responses at different levels. Here we discuss the influence of autophagy on selfautonomous, innate and adaptive immunity and then focus on how bacterial mechanisms that shape autophagy may impact the host immune system.
Keywords: manipulation; autophagy; bacterial; pathogens; impacts; immunity manipulation; autophagy; bacterial; pathogens; impacts; immunity

Share and Cite

MDPI and ACS Style

Kunz, T.C.; Viana, F.; Buchrieser, C.; Escoll, P. Manipulation of Autophagy by Bacterial Pathogens Impacts Host Immunity. Curr. Issues Mol. Biol. 2018, 25, 81-98. https://doi.org/10.21775/cimb.025.081

AMA Style

Kunz TC, Viana F, Buchrieser C, Escoll P. Manipulation of Autophagy by Bacterial Pathogens Impacts Host Immunity. Current Issues in Molecular Biology. 2018; 25(1):81-98. https://doi.org/10.21775/cimb.025.081

Chicago/Turabian Style

Kunz, Tobias C., Flávia Viana, Carmen Buchrieser, and Pedro Escoll. 2018. "Manipulation of Autophagy by Bacterial Pathogens Impacts Host Immunity" Current Issues in Molecular Biology 25, no. 1: 81-98. https://doi.org/10.21775/cimb.025.081

APA Style

Kunz, T. C., Viana, F., Buchrieser, C., & Escoll, P. (2018). Manipulation of Autophagy by Bacterial Pathogens Impacts Host Immunity. Current Issues in Molecular Biology, 25(1), 81-98. https://doi.org/10.21775/cimb.025.081

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