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Volume 21
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10.21775/cimb.021.063
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Mycobacteria and Autophagy: Many Questions and Few Answers

by
Min Liang
1,†,
Zeshan Habib
1,†,
Kaori Sakamoto
2,
Xi Chen
1,3,* and
Gang Cao
1,*
1
State-Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China
2
Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
3
College of Informatics, Huazhong Agricultural University, Wuhan 430070, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Issues Mol. Biol. 2017, 21(1), 63-72; https://doi.org/10.21775/cimb.021.063
Submission received: 12 May 2016 / Revised: 10 June 2016 / Accepted: 14 June 2016 / Published: 23 July 2016

Abstract

Tuberculosis (TB) is an ancient disease caused by Mycobacterium tuberculosis (Mtb). TB is one of the world’s deadliest diseases, with one-third of infected individuals falling ill each year especially in many developing countries. Upon invading host cells, such as macrophages, Mtb can replicate in infected cells by arresting phagosome maturation and then potentially escaping into the cytosol. Host cells have a mechanism to control intracellular Mtb by inducing autophagy, which is an elaborate cellular process to target intracellular pathogens for degradation in infected cells. However, some factors of Mtb are involved in defense against killing by autophagy. Thus, this review highlights the recent advances in the interactions between autophagy and Mtb.

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MDPI and ACS Style

Liang, M.; Habib, Z.; Sakamoto, K.; Chen, X.; Cao, G. Mycobacteria and Autophagy: Many Questions and Few Answers. Curr. Issues Mol. Biol. 2017, 21, 63-72. https://doi.org/10.21775/cimb.021.063

AMA Style

Liang M, Habib Z, Sakamoto K, Chen X, Cao G. Mycobacteria and Autophagy: Many Questions and Few Answers. Current Issues in Molecular Biology. 2017; 21(1):63-72. https://doi.org/10.21775/cimb.021.063

Chicago/Turabian Style

Liang, Min, Zeshan Habib, Kaori Sakamoto, Xi Chen, and Gang Cao. 2017. "Mycobacteria and Autophagy: Many Questions and Few Answers" Current Issues in Molecular Biology 21, no. 1: 63-72. https://doi.org/10.21775/cimb.021.063

APA Style

Liang, M., Habib, Z., Sakamoto, K., Chen, X., & Cao, G. (2017). Mycobacteria and Autophagy: Many Questions and Few Answers. Current Issues in Molecular Biology, 21(1), 63-72. https://doi.org/10.21775/cimb.021.063

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