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Volume 20
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10.21775/cimb.020.047
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Novel Attributions of TREMs in Immunity

by
Nuruliarizki Shinta Pandupuspitasari
†,
Faheem Ahmed Khan
†,
Chun-Jie Huang
,
Xing Chen
and
ShuJun Zhang
*
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education China, Huazhong Agricultural University, Wuhan 430070, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Issues Mol. Biol. 2016, 20(1), 47-54; https://doi.org/10.21775/cimb.020.047
Submission received: 3 September 2015 / Revised: 14 October 2015 / Accepted: 6 November 2015 / Published: 7 January 2016

Abstract

The emerging role of the TREMs (Triggering Receptors Expressed by Myeloid cells) family in inflammation makes it important to explore their molecular mechanisms governing key pathways in inflammatory diseases. The TREMs family interaction with microbial products make it a strong candidate to target inflammatory diseases and raises an important question of its potential as a useful target in inflammatory diseases caused by products other than microbes, for example psoriasis. The interaction of TREMs with various immune responses can be of key importance in handling inflammatory diseases. The well established interaction of TREM-1 with microbial products like LPS and the emerging interactions with products from different important diseases of brain, heart, lungs and skin demands its full investigation as a therapeutic target. The post translational modifications (PTMs) that might regulate the functions of genes are also discussed and its future potential is reviewed. Furthermore, Its close cross talk with TLRs, NLRs and NODs is also reviewed in context of developing novel therapeutics.

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MDPI and ACS Style

Pandupuspitasari, N.S.; Khan, F.A.; Huang, C.-J.; Chen, X.; Zhang, S. Novel Attributions of TREMs in Immunity. Curr. Issues Mol. Biol. 2016, 20, 47-54. https://doi.org/10.21775/cimb.020.047

AMA Style

Pandupuspitasari NS, Khan FA, Huang C-J, Chen X, Zhang S. Novel Attributions of TREMs in Immunity. Current Issues in Molecular Biology. 2016; 20(1):47-54. https://doi.org/10.21775/cimb.020.047

Chicago/Turabian Style

Pandupuspitasari, Nuruliarizki Shinta, Faheem Ahmed Khan, Chun-Jie Huang, Xing Chen, and ShuJun Zhang. 2016. "Novel Attributions of TREMs in Immunity" Current Issues in Molecular Biology 20, no. 1: 47-54. https://doi.org/10.21775/cimb.020.047

APA Style

Pandupuspitasari, N. S., Khan, F. A., Huang, C.-J., Chen, X., & Zhang, S. (2016). Novel Attributions of TREMs in Immunity. Current Issues in Molecular Biology, 20(1), 47-54. https://doi.org/10.21775/cimb.020.047

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