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Volume 12
Issue 3
10.21775/cimb.012.143
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

p53-Based Anti-Cancer Therapies: An Empty Promise?

by
Nikolas Desilet
1,
Tessa N. Campbell
2 and
Francis Y.M. Choy
1,*
1
Department of Biology, University of Victoria, Victoria, BC, Canada
2
Department of Oncology, Southern Alberta Cancer Research Institute, University of Calgary, Calgary, AB, Canada
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2010, 12(3), 143-146; https://doi.org/10.21775/cimb.012.143
Submission received: 5 July 2009 / Revised: 10 July 2009 / Accepted: 14 September 2009 / Published: 16 November 2009

Abstract

Since its discovery in 1979, p53 has become the focus of intensive cancer-based research in laboratories around the world. The p53 protein mediates critical cellular functions including the response to genotoxic stress, differentiation, senescence, and apoptosis, and has been shown to be mutated in a large proportion of human cancers. These observations led many to speculate that targeting the p53 pathway would result in the development of successful anti-cancer treatments. In spite of this, 30 years later, p53 has yet to fulfill this promise. However, new insights into small molecule combination therapies, microRNA regulation, structuring of clinical trials, and potential involvement in stem cell regulation may help p53 reach its potential.
Keywords: p53; cancer-based research; genotoxic stress; differentiation; senescence; apoptosis; anti-cancer treatments; combination therapies; microRNA regulation; stem cell regulation p53; cancer-based research; genotoxic stress; differentiation; senescence; apoptosis; anti-cancer treatments; combination therapies; microRNA regulation; stem cell regulation

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MDPI and ACS Style

Desilet, N.; Campbell, T.N.; Choy, F.Y.M. p53-Based Anti-Cancer Therapies: An Empty Promise? Curr. Issues Mol. Biol. 2010, 12, 143-146. https://doi.org/10.21775/cimb.012.143

AMA Style

Desilet N, Campbell TN, Choy FYM. p53-Based Anti-Cancer Therapies: An Empty Promise? Current Issues in Molecular Biology. 2010; 12(3):143-146. https://doi.org/10.21775/cimb.012.143

Chicago/Turabian Style

Desilet, Nikolas, Tessa N. Campbell, and Francis Y.M. Choy. 2010. "p53-Based Anti-Cancer Therapies: An Empty Promise?" Current Issues in Molecular Biology 12, no. 3: 143-146. https://doi.org/10.21775/cimb.012.143

APA Style

Desilet, N., Campbell, T. N., & Choy, F. Y. M. (2010). p53-Based Anti-Cancer Therapies: An Empty Promise? Current Issues in Molecular Biology, 12(3), 143-146. https://doi.org/10.21775/cimb.012.143

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