Next Article in Journal
Announcing the 2016 Pharmaceuticals Travel Award for Young Investigators
Previous Article in Journal
Tumor Heterogeneity, Single-Cell Sequencing, and Drug Resistance
Open AccessArticle

Relationship between Surface Properties and In Vitro Drug Release from a Compressed Matrix Containing an Amphiphilic Polymer Material

Pharmaceutical Physical Chemistry Laboratory, Natura Research Group, Pharmaceutical Chemistry Program, Faculty of Natural Sciences, ICESI University, Cali 760031, Colombia
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas Rades
Pharmaceuticals 2016, 9(3), 34; https://doi.org/10.3390/ph9030034
Received: 7 March 2016 / Revised: 3 June 2016 / Accepted: 20 June 2016 / Published: 24 June 2016
The performance of compressed tablet drug delivery systems made using polymeric materials depend on multiple factors, such as surface properties like contact angle, surface free energy and water absorption rate, besides the release mechanisms driven by the kind of polymer used. Hence, it should be possible to establish a relationship between the surface properties and the drug release kinetics. Compressed tablets with different proportions of poly(maleic acid-alt-octadecene) potassium salt (0%, 10%, 20%, 30% and 40%) were prepared. Blends of a model drug (ampicillin trihydrate) and the polymer material were analyzed by DSC. The surface properties of the tablets were determined by the sessile drop method, while the surface energy was determined using the semi-empirical Young-Dupre, Neumann and OWRK models. The release profiles were determined simulating in vitro conditions (buffer solutions pH 1.2 and pH 7.4 with ionic strength of 1.5 M at 37 °C (310.15 K)). A kinetic analysis of the dissolution profiles using different models (zero order, first order, Higuchi and Korsmeyer-Peppas) was realized. The results showed a significant effect of the proportion of polymer in both the surface properties of the tablets and the dissolution release, indicating a relationship between the kinetic and thermodynamic properties. View Full-Text
Keywords: surface free energy; surface properties; drug release; amphiphilic polymer surface free energy; surface properties; drug release; amphiphilic polymer
Show Figures

Graphical abstract

MDPI and ACS Style

Yarce, C.J.; Pineda, D.; Correa, C.E.; Salamanca, C.H. Relationship between Surface Properties and In Vitro Drug Release from a Compressed Matrix Containing an Amphiphilic Polymer Material. Pharmaceuticals 2016, 9, 34.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop