Scolicidal and Apoptotic Activities of 5-hydroxy-1, 4-naphthoquinone as a Potent Agent against Echinococcus granulosus Protoscoleces
Abstract
:1. Introduction
2. Results
2.1. Morphology and Zeta Potential Characterization of Liposomal Systems Containing Juglone
2.2. Genotyping of E. granulosus PSCs
2.3. Scolicidal Effects of Juglone and Juglone Nanoliposomes
2.4. Expression of caspase-3 Gene
3. Discussion
4. Materials and Methods
4.1. Preparation of Juglone
4.2. Preparation of Liposomal Systems Containing of Juglone
4.3. Size and Zeta Potential Characterizationof Juglonein Liposomal Systems
4.4. Morphology of Liposomal Systems Containing Juglone
4.5. Collection of E. granulosus PSCs
4.6. Genotyping the PSCs
4.7. Scolicidal Assay
4.8. Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR)
4.9. Statistical Analysis of Data
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Moghadaszadeh, M.; Khayyati, M.; Spotin, A.; Norouzi, R.; Pagheh, A.S.; Oliveira, S.M.R.; Pereira, M.d.L.; Ahmadpour, E. Scolicidal and Apoptotic Activities of 5-hydroxy-1, 4-naphthoquinone as a Potent Agent against Echinococcus granulosus Protoscoleces. Pharmaceuticals 2021, 14, 623. https://doi.org/10.3390/ph14070623
Moghadaszadeh M, Khayyati M, Spotin A, Norouzi R, Pagheh AS, Oliveira SMR, Pereira MdL, Ahmadpour E. Scolicidal and Apoptotic Activities of 5-hydroxy-1, 4-naphthoquinone as a Potent Agent against Echinococcus granulosus Protoscoleces. Pharmaceuticals. 2021; 14(7):623. https://doi.org/10.3390/ph14070623
Chicago/Turabian StyleMoghadaszadeh, Masoud, Mehdi Khayyati, Adel Spotin, Roghayeh Norouzi, Abdol Sattar Pagheh, Sonia M. R. Oliveira, Maria de Lourdes Pereira, and Ehsan Ahmadpour. 2021. "Scolicidal and Apoptotic Activities of 5-hydroxy-1, 4-naphthoquinone as a Potent Agent against Echinococcus granulosus Protoscoleces" Pharmaceuticals 14, no. 7: 623. https://doi.org/10.3390/ph14070623
APA StyleMoghadaszadeh, M., Khayyati, M., Spotin, A., Norouzi, R., Pagheh, A. S., Oliveira, S. M. R., Pereira, M. d. L., & Ahmadpour, E. (2021). Scolicidal and Apoptotic Activities of 5-hydroxy-1, 4-naphthoquinone as a Potent Agent against Echinococcus granulosus Protoscoleces. Pharmaceuticals, 14(7), 623. https://doi.org/10.3390/ph14070623