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Sensors 2018, 18(2), 599;

Responsive Polydiacetylene Vesicles for Biosensing Microorganisms

Institute of Analytical Sciences, University of Lyon, 69100 Villeurbanne, France
Institute of Chemical Sciences, University of Rennes 1, 35000 Rennes, France
University of Lyon, LAGEP, 69622 Villeurbanne, France
Authors to whom correspondence should be addressed.
Received: 12 January 2018 / Revised: 11 February 2018 / Accepted: 14 February 2018 / Published: 15 February 2018
(This article belongs to the Special Issue Polymer-Based Sensors for Bioanalytes)
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Polydiacetylene (PDA) inserted in films or in vesicles has received increasing attention due to its property to undergo a blue-to-red colorimetric transition along with a change from non-fluorescent to fluorescent upon application of various stimuli. In this review paper, the principle for the detection of various microorganisms (bacteria, directly detected or detected through the emitted toxins or through their DNA, and viruses) and of antibacterial and antiviral peptides based on these responsive PDA vesicles are detailed. The analytical performances obtained, when vesicles are in suspension or immobilized, are given and compared to those of the responsive vesicles mainly based on the vesicle encapsulation method. Many future challenges are then discussed. View Full-Text
Keywords: vesicles; polydiacetylene; biosensing; bacteria; toxins; virus; peptides vesicles; polydiacetylene; biosensing; bacteria; toxins; virus; peptides

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Lebègue, E.; Farre, C.; Jose, C.; Saulnier, J.; Lagarde, F.; Chevalier, Y.; Chaix, C.; Jaffrezic-Renault, N. Responsive Polydiacetylene Vesicles for Biosensing Microorganisms. Sensors 2018, 18, 599.

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