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Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy

Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230027, China
Author to whom correspondence should be addressed.
Sensors 2017, 17(7), 1592;
Received: 24 May 2017 / Revised: 4 July 2017 / Accepted: 4 July 2017 / Published: 7 July 2017
(This article belongs to the Special Issue Applications of Raman Spectroscopy in Biosensors)
Raman spectroscopy is a label-free method of obtaining detailed chemical information about samples. Its compatibility with living tissue makes it an attractive choice for biomedical analysis, yet its translation from a research tool to a clinical tool has been slow, hampered by fundamental Raman scattering issues such as long integration times and limited penetration depth. In this review we detail the how combining Raman spectroscopy with other techniques yields multimodal instruments that can help to surmount the translational barriers faced by Raman alone. We review Raman combined with several optical and non-optical methods, including fluorescence, elastic scattering, OCT, phase imaging, and mass spectrometry. In each section we highlight the power of each combination along with a brief history and presentation of representative results. Finally, we conclude with a perspective detailing both benefits and challenges for multimodal Raman measurements, and give thoughts on future directions in the field. View Full-Text
Keywords: Raman spectroscopy; multimodal; light scattering Raman spectroscopy; multimodal; light scattering
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Das, N.K.; Dai, Y.; Liu, P.; Hu, C.; Tong, L.; Chen, X.; Smith, Z.J. Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy. Sensors 2017, 17, 1592.

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