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Open AccessArticle

Electrochemical Aptasensor for Myoglobin-Specific Recognition Based on Porphyrin Functionalized Graphene-Conjugated Gold Nanocomposites

1
Institute of Environmental Science, Shanxi University, Taiyuan 030006, China
2
College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
*
Author to whom correspondence should be addressed.
Academic Editor: Huangxian Ju
Sensors 2016, 16(11), 1803; https://doi.org/10.3390/s16111803
Received: 9 September 2016 / Revised: 13 October 2016 / Accepted: 22 October 2016 / Published: 28 October 2016
(This article belongs to the Special Issue Nanobiosensing for Sensors)
In this work, a novel electrochemical aptasensor was developed for sensitive and selective detection of myoglobin based on meso-tetra (4-carboxyphenyl) porphyrin-functionalized graphene-conjugated gold nanoparticles (TCPP–Gr/AuNPs). Due to its good electric conductivity, large specific surface area, and excellent mechanical properties, TCPP–Gr/AuNPs can act as an enhanced material for the electrochemical detection of myoglobin. Meanwhile, it provides an effective matrix for immobilizing myoglobin-binding aptamer (MbBA). The electrochemical aptasensor has a sensitive response to myoglobin in a linear range from 2.0 × 10−11 M to 7.7 × 10−7 M with a detection limit of 6.7 × 10−12 M (S/N = 3). Furthermore, the method has the merits of high sensitivity, low price, and high specificity. Our work will supply new horizons for the diagnostic applications of graphene-based materials in biomedicine and biosensors. View Full-Text
Keywords: graphene; TCPP; AuNPs; myoglobin graphene; TCPP; AuNPs; myoglobin
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Zhang, G.; Liu, Z.; Wang, L.; Guo, Y. Electrochemical Aptasensor for Myoglobin-Specific Recognition Based on Porphyrin Functionalized Graphene-Conjugated Gold Nanocomposites. Sensors 2016, 16, 1803.

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