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Open AccessArticle

Electrochemical Aptasensor for Myoglobin-Specific Recognition Based on Porphyrin Functionalized Graphene-Conjugated Gold Nanocomposites

Institute of Environmental Science, Shanxi University, Taiyuan 030006, China
College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
Author to whom correspondence should be addressed.
Academic Editor: Huangxian Ju
Sensors 2016, 16(11), 1803;
Received: 9 September 2016 / Revised: 13 October 2016 / Accepted: 22 October 2016 / Published: 28 October 2016
(This article belongs to the Special Issue Nanobiosensing for Sensors)
In this work, a novel electrochemical aptasensor was developed for sensitive and selective detection of myoglobin based on meso-tetra (4-carboxyphenyl) porphyrin-functionalized graphene-conjugated gold nanoparticles (TCPP–Gr/AuNPs). Due to its good electric conductivity, large specific surface area, and excellent mechanical properties, TCPP–Gr/AuNPs can act as an enhanced material for the electrochemical detection of myoglobin. Meanwhile, it provides an effective matrix for immobilizing myoglobin-binding aptamer (MbBA). The electrochemical aptasensor has a sensitive response to myoglobin in a linear range from 2.0 × 10−11 M to 7.7 × 10−7 M with a detection limit of 6.7 × 10−12 M (S/N = 3). Furthermore, the method has the merits of high sensitivity, low price, and high specificity. Our work will supply new horizons for the diagnostic applications of graphene-based materials in biomedicine and biosensors. View Full-Text
Keywords: graphene; TCPP; AuNPs; myoglobin graphene; TCPP; AuNPs; myoglobin
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Zhang, G.; Liu, Z.; Wang, L.; Guo, Y. Electrochemical Aptasensor for Myoglobin-Specific Recognition Based on Porphyrin Functionalized Graphene-Conjugated Gold Nanocomposites. Sensors 2016, 16, 1803.

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