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Sensors 2015, 15(5), 9915-9927;

Development of a HIV-1 Virus Detection System Based on Nanotechnology

Department of Chemical & Biomolecular Engineering, Sogang University, #1 Shinsu-Dong, Mapo-Gu, Seoul 121-742, Korea
Author to whom correspondence should be addressed.
Academic Editor: Stephane Evoy
Received: 5 March 2015 / Revised: 8 April 2015 / Accepted: 20 April 2015 / Published: 27 April 2015
(This article belongs to the Special Issue Biosensors for Pathogen Detection)
Full-Text   |   PDF [2380 KB, uploaded 27 April 2015]   |  


Development of a sensitive and selective detection system for pathogenic viral agents is essential for medical healthcare from diagnostics to therapeutics. However, conventional detection systems are time consuming, resource-intensive and tedious to perform. Hence, the demand for sensitive and selective detection system for virus are highly increasing. To attain this aim, different aspects and techniques have been applied to develop virus sensor with improved sensitivity and selectivity. Here, among those aspects and techniques, this article reviews HIV virus particle detection systems incorporated with nanotechnology to enhance the sensitivity. This review mainly focused on four different detection system including vertically configured electrical detection based on scanning tunneling microscopy (STM), electrochemical detection based on direct electron transfer in virus, optical detection system based on localized surface plasmon resonance (LSPR) and surface enhanced Raman spectroscopy (SERS) using plasmonic nanoparticle. View Full-Text
Keywords: detection system; HIV-1 virus; electrical; electrochemical; optical; nanoparticle detection system; HIV-1 virus; electrical; electrochemical; optical; nanoparticle

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Lee, J.-H.; Oh, B.-K.; Choi, J.-W. Development of a HIV-1 Virus Detection System Based on Nanotechnology. Sensors 2015, 15, 9915-9927.

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